Bratisl Lek Listy. 2021;122(4):256-262. doi: 10.4149/BLL_2021_042.
This study aims to investigate whether there is a relationship between attention-deficit/hyperactivity disorder (ADHD) and inflammation, using hematologic inflammatory parameters in a large sample of children and adolescents.
This retrospective study comprises 347 children and adolescents with ADHD between 6 and 17 years of age who met the inclusion criteria as well as 205 healthy children and adolescents in the control group. Serum parameters such as white blood cell (WBC), neutrophil, lymphocyte, platelet, monocyte, eosinophil and basophil counts, mean platelet volume (MPV), and platelet distribution width (PDW) were recorded from complete blood count tests at the time of admission, while neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and other ratios were calculated based on these counts.
NLR, PLR, MPV, PDW, WBC and neutrophil counts were significantly higher in children and adolescents with ADHD than in the control group. In the ADHD group, NLR, WBC and neutrophil counts were significantly higher in girls than in boys.
The results of this study support the hypothesis that inflammation plays an important role in the complex pathophysiology of ADHD. In addition, our data confirm that easily obtainable and reliable hematological parameters can be used when investigating the role of inflammation in ADHD etiology (Tab. 4, Ref. 44).
本研究旨在通过对大量儿童和青少年的血液学炎症参数进行研究，探讨注意缺陷多动障碍（ADHD）与炎症之间是否存在关联。
本回顾性研究纳入了 347 名符合纳入标准的 6-17 岁 ADHD 患儿及 205 名健康对照儿童，记录其入院时全血细胞计数检测中的血清参数，如白细胞（WBC）、中性粒细胞、淋巴细胞、血小板、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞计数、平均血小板体积（MPV）和血小板分布宽度（PDW），并基于这些计数计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和其他比值。
与对照组相比，ADHD 患儿的 NLR、PLR、MPV、PDW、WBC 和中性粒细胞计数显著升高。在 ADHD 组中，女孩的 NLR、WBC 和中性粒细胞计数显著高于男孩。
本研究结果支持炎症在 ADHD 复杂病理生理学中起重要作用的假说。此外，我们的数据证实，在研究炎症在 ADHD 病因学中的作用时，可以使用容易获得且可靠的血液学参数（表 4，参考文献 44）。
