Tamura Kentaro, Nishioka Saiko, Tamura Nobumasa, Saito Zenya, Kuwano Kazuyoshi
Division of Respiratory Diseases, Department of Internal Medicine, Atsugi City Hospital, Kanagawa, 243-8588, Japan.
Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
Respir Med Case Rep. 2020;31:101318. doi: 10.1016/j.rmcr.2020.101318. Epub 2020 Dec 9.
Although some prospective studies provided the evidence of corticosteroids for critically ill patients with COVID-19, the optimal dosage or timing of corticosteroids is still unknown. This is a case series of four patients on methyl-prednisolone pulses for the late phase of Coronavirus disease 2019 (COVID-19) with respiratory failure in our hospital. All patients needed invasive mechanical ventilation and had bimodal worseness of their respiratory status with consolidation and volume loss after intubation. All cases could successfully discontinue oxygen therapy without any severe adverse events after this pulse therapy in the late phase of COVID-19. This therapy is believed to be effective on some optimal patients. Hence, further studies to explore this efficacy and safety were needed.
尽管一些前瞻性研究为患有新型冠状病毒肺炎（COVID-19）的危重症患者使用皮质类固醇提供了证据，但皮质类固醇的最佳剂量或使用时机仍不清楚。这是我院收治的4例在2019冠状病毒病（COVID-19）晚期因呼吸衰竭接受甲泼尼龙冲击治疗的病例系列。所有患者均需要有创机械通气，且在插管后出现呼吸状态双峰性恶化，伴有实变和肺容积减少。在COVID-19晚期进行这种冲击治疗后，所有病例均能成功停用氧疗，且未发生任何严重不良事件。这种治疗方法被认为对某些合适的患者有效。因此，需要进一步研究以探索这种治疗方法的有效性和安全性。
