Tazelaar H D, Billingham M E
Department of Pathology, Stanford University Medical Center, California.
Am J Cardiovasc Pathol. 1987 Jan;1(1):47-50.
The diagnosis of active lymphocytic myocarditis by the use of the endomyocardial bioptome is at present a hotly debated topic. However, the question of whether lymphocytes reside in the myocardium of individuals without systemic or cardiac disease has rarely been addressed, but is obviously of critical importance in helping to resolve this issue. Therefore, we examined endomyocardial biopsies obtained from 86 young heart disease-free cardiac transplant donors at the time of transplantation. Foci of inflammatory cells were found in eight (9.3%) cases and by definition contained greater than five inflammatory cells per focus. The inflammatory infiltrates were predominantly lymphocytic. Based on these results and those of others, it is becoming evident that there is a normal myocardial lymphocyte population which must be reckoned with when considering the diagnosis of myocarditis, realizing the potential therapeutic implications of this diagnosis.
目前，使用心内膜活检钳诊断活动性淋巴细胞性心肌炎是一个备受争议的话题。然而，淋巴细胞是否存在于无全身性或心脏疾病个体的心肌中这一问题很少有人提及，但显然对于解决这一问题至关重要。因此，我们检查了86例年轻且无心脏病的心脏移植供体在移植时获取的心内膜活检组织。在8例（9.3%）病例中发现了炎症细胞灶，根据定义，每个病灶含有超过5个炎症细胞。炎症浸润主要为淋巴细胞。基于这些结果以及其他研究结果，越来越明显的是，存在一个正常的心肌淋巴细胞群体，在考虑心肌炎诊断时必须加以考虑，同时要认识到这一诊断潜在的治疗意义。
