Guy’s Hospital, London, UK.
University of Sassari, Italy.
Rhinology. 2021 Feb 1;59(1):26-31. doi: 10.4193/Rhin20.544.
Loss of smell and taste is now recognised as amongst the most common symptoms of COVID-19 and the best predictor of COVID-19 positivity. Long term outcomes are unknown. This study aims to investigate recovery of loss of smell and the prevalence of parosmia.
6-month follow-up of respondents to an online surgery who self-reported loss of smell at the onset of the CO- VID-19 pandemic in the UK. Information of additional symptoms, recovery of loss of smell and the development of parosmia was collected.
44% of respondents reported at least one other ongoing symptom at 6 months, of which fatigue (n=106) was the most prevalent. There was a significant improvement in self-rating of severity of olfactory loss where 177 patients stated they had a normal smell of smell while 12 patients reported complete loss of smell. The prevalence of parosmia is 43.1% with median interval of 2.5 months (range 0-6) from the onset of loss of smell.
While many patients recover quickly, some experience long-term deficits with no self-reported improvement at 6 months. Furthermore, there is a high prevalence of parosmia even in those who report at least some recovery of olfactory func- tion. Longer term evaluation of recovery is required.
嗅觉丧失现在被认为是 COVID-19 最常见的症状之一,也是 COVID-19 阳性的最佳预测指标。长期结果尚不清楚。本研究旨在调查嗅觉丧失的恢复情况和恶臭的患病率。
对英国 COVID-19 大流行期间在线手术中自我报告嗅觉丧失的受访者进行 6 个月的随访。收集了有关其他症状、嗅觉丧失的恢复情况和恶臭发展的信息。
44%的受访者在 6 个月时报告至少有一种持续存在的其他症状,其中疲劳(n=106)最为常见。嗅觉丧失严重程度的自我评估有显著改善,177 名患者表示嗅觉正常,12 名患者报告嗅觉完全丧失。恶臭的患病率为 43.1%,嗅觉丧失的中位数间隔为 2.5 个月(范围为 0-6)。
虽然许多患者恢复得很快,但有些患者在 6 个月时仍长期存在嗅觉丧失,且没有自我报告的改善。此外,即使那些报告嗅觉功能至少有部分恢复的患者,恶臭的患病率也很高。需要对恢复情况进行更长期的评估。