Institute of Cell Dynamics and Imaging, University of Münster, Münster, Germany
Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, Münster, Germany.
J Cell Biol. 2018 Dec 3;217(12):4053-4054. doi: 10.1083/jcb.201811021. Epub 2018 Nov 15.
The lipid droplet (LD) biogenesis protein seipin is crucial for formation of normal LDs, but its exact functional role has been enigmatic. In this issue, Sui et al. (2018. https://doi.org/10.1083/jcb.201809067) report the cryo--electron microscopy structure of seipin, which provides novel insights into how seipin might mediate LD formation.
脂滴（LD）生物发生蛋白 seipin 对于正常 LD 的形成至关重要，但它的确切功能作用一直是个谜。在本期中，Sui 等人（2018. https://doi.org/10.1083/jcb.201809067）报道了 seipin 的冷冻电镜结构，这为 seipin 如何介导 LD 形成提供了新的见解。
