Shen Jie, Lu Zhiguo, Wang Jianze, Zhang Tianlu, Yang Jun, Li Yan, Liu Guiying, Zhang Xin
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
ACS Biomater Sci Eng. 2020 Dec 14;6(12):6478-6489. doi: 10.1021/acsbiomaterials.0c01040. Epub 2020 Nov 20.
Leukemia is a liquid tumor caused by a hematopoietic stem cell malignant clone, which seriously affects the normal function of the hematopoietic system. Conventional drugs have poor therapeutic effects due to their poor specificity and stability. With the development of nanotechnology, nonviral nanoparticles bring hope for the efficient treatment of leukemia. Nanoparticles are easily modified. They can be designed to target lesion sites and control drug release. Thereby, nanoparticles can improve the effects of drugs and reduce side effects. This review mainly focuses on and summarizes the current research progress of nanoparticles to deliver different leukemia therapeutic drugs, as to demonstrate the potential of nanoparticles in leukemia treatment.
白血病是一种由造血干细胞恶性克隆引起的血液肿瘤,严重影响造血系统的正常功能。传统药物由于特异性和稳定性差,治疗效果不佳。随着纳米技术的发展,非病毒纳米颗粒为白血病的有效治疗带来了希望。纳米颗粒易于修饰。它们可以被设计成靶向病变部位并控制药物释放。因此,纳米颗粒可以提高药物疗效并减少副作用。本文综述主要聚焦并总结纳米颗粒递送不同白血病治疗药物的当前研究进展,以展示纳米颗粒在白血病治疗中的潜力。