Khan Suliman, Hasan Anwarul, Attar Farnoosh, Sharifi Majid, Siddique Rabeea, Mraiche Fatima, Falahati Mojtaba
Department of Cerebrovascular Diseases, the Second Affiliated Hospital of Zhengzhou University, Jingba Road, NO.2, 450014 Zhengzhou, China.
Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar.
ACS Biomater Sci Eng. 2020 Dec 14;6(12):6460-6477. doi: 10.1021/acsbiomaterials.0c00955. Epub 2020 Nov 17.
In recent years, an increasing rate of mortality due to myocardial infarction (MI) has led to the development of nanobased platforms, especially gold nanoparticles (AuNPs), as promising nanomaterials for diagnosis and treatment of MI. These promising NPs have been used to develop different nanobiosensors, mainly optical sensors for early detection of biomarkers as well as biomimetic/bioinspired platforms for cardiac tissue engineering (CTE). Therefore, in this Review, we presented an overview on the potential application of AuNPs as optical (surface plasmon resonance, colorimetric, fluorescence, and chemiluminescence) nanobiosensors for early diagnosis and prognosis of MI. On the other hand, we discussed the potential application of AuNPs either alone or with other NPs/polymers as promising three-dimensional (3D) scaffolds to regulate the microenvironment and mimic the morphological and electrical features of cardiac cells for potential application in CTE. Furthermore, we presented the challenges and ongoing efforts associated with the application of AuNPs in the diagnosis and treatment of MI. In conclusion, this Review may provide outstanding information regarding the development of AuNP-based technology as a promising platform for current MI treatment approaches.
近年来，心肌梗死（MI）导致的死亡率不断上升，促使基于纳米的平台，特别是金纳米颗粒（AuNPs）的发展，成为用于MI诊断和治疗的有前景的纳米材料。这些有前景的纳米颗粒已被用于开发不同的纳米生物传感器，主要是用于早期检测生物标志物的光学传感器以及用于心脏组织工程（CTE）的仿生/受生物启发的平台。因此，在本综述中，我们概述了AuNPs作为光学（表面等离子体共振、比色、荧光和化学发光）纳米生物传感器在MI早期诊断和预后中的潜在应用。另一方面，我们讨论了AuNPs单独或与其他纳米颗粒/聚合物一起作为有前景的三维（3D）支架的潜在应用，以调节微环境并模拟心脏细胞的形态和电学特征，用于CTE的潜在应用。此外，我们介绍了与AuNPs在MI诊断和治疗中的应用相关的挑战和正在进行的努力。总之，本综述可能会提供有关基于AuNP的技术作为当前MI治疗方法的有前景平台的发展的出色信息。
