Xu Feng, Jin Hang, Liu Lingling, Yang Yuanyuan, Cen Jianzheng, Wu Yaobin, Chen Songyue, Sun Daoheng
Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen, 361102 China.
Guangdong Provincial People's Hospital, Guangzhou, 510080 China.
Microsyst Nanoeng. 2024 Jul 11;10:96. doi: 10.1038/s41378-024-00692-7. eCollection 2024.
Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for the development of engineered cardiac tissue, facilitating high-throughput testing in drug development and clinical treatment. HoC is primarily used to create a biomimetic microphysiological environment conducive to fostering the maturation of cardiac tissue and to gather information regarding the real-time condition of cardiac tissue. The development of architectural design and advanced manufacturing for these "3S" components, scaffolds, stimulation, and sensors is essential for improving the maturity of cardiac tissue cultivated on-chip, as well as the precision and accuracy of tissue states. In this review, the typical structures and manufacturing technologies of the "3S" components are summarized. The design and manufacturing suggestions for each component are proposed. Furthermore, key challenges and future perspectives of HoC platforms with integrated "3S" components are discussed. Architecture design concepts of scaffolds, stimulation and sensors in chips.
芯片上心脏（HoC）已成为一种高效、经济的用于工程化心脏组织开发的设备，有助于在药物研发和临床治疗中进行高通量测试。HoC主要用于创建一个有利于促进心脏组织成熟的仿生微生理环境，并收集有关心脏组织实时状况的信息。这些“3S”组件（支架、刺激和传感器）的架构设计和先进制造技术的发展对于提高芯片上培养的心脏组织的成熟度以及组织状态的精确性和准确性至关重要。在本综述中，总结了“3S”组件的典型结构和制造技术。针对每个组件提出了设计和制造建议。此外，还讨论了集成“3S”组件的HoC平台的关键挑战和未来展望。芯片中支架、刺激和传感器的架构设计概念。
