Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Tehran, Iran.
Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
PLoS One. 2020 Dec 15;15(12):e0243600. doi: 10.1371/journal.pone.0243600. eCollection 2020.
Based on the epidemiologic findings of Covid-19 incidence; illness and mortality seem to be associated with metabolic risk factors. This systematic review and meta-analysis aimed to assess the association of metabolic risk factors and risk of Covid-19.
This study was designed according to PRISMA guidelines. Two independent researchers searched for the relevant studies using PubMed, Web of Science, Cochrane Library, and Scopus. The search terms developed focusing on two main roots of "Covid-19" and "metabolic risk factors". All relevant observational, analytical studies, review articles, and a meta-analysis on the adult population were included in this meta-analysis. Meta-analysis was performed using the random effect model for pooling proportions to address heterogeneity among studies. Data were analyzed using STATA package version 11.2, (StataCorp, USA).
Through a comprehensive systematic search in the targeted databases we found 1124 papers, after running the proses of refining, 13 studies were included in the present meta-analysis. The pooled prevalence of obesity in Covid-19 patients was 29% (95% CI: 14-47%). For Diabetes and Hypertension, these were 22% (95% CI: 12% 33%) and 32% (95% CI: 12% 56%), respectively. There was significant heterogeneity in the estimates of the three pooled prevalence without any significant small-study effects. Such warning points, to some extent, guide physicians and clinicians to better understand the importance of controlling co-morbid risk factors in prioritizing resource allocation and interventions.
The meta-analysis showed that hypertension is more prevalent than obesity and diabetes in patients with Covid-19 disease. The prevalence of co-morbid metabolic risk factors must be adopted for better management and priority settings of public health vaccination and other required interventions. The results may help to improve services delivery in COVID-19 patients, while helping to develop better policies for prevention and response to COVID-19 and its critical outcomes.
基于新冠病毒发病率的流行病学研究结果；疾病和死亡率似乎与代谢危险因素有关。本系统评价和荟萃分析旨在评估代谢危险因素与新冠病毒风险之间的关联。
本研究根据 PRISMA 指南设计。两名独立研究人员使用 PubMed、Web of Science、Cochrane Library 和 Scopus 搜索相关研究。制定的搜索术语主要集中在“新冠病毒”和“代谢危险因素”两个根源上。本荟萃分析纳入了所有针对成年人群的相关观察性、分析性研究、综述文章和荟萃分析。使用随机效应模型对汇总比例进行荟萃分析，以解决研究之间的异质性。使用 STATA 软件包版本 11.2（StataCorp，美国）进行数据分析。
通过在目标数据库中进行全面的系统搜索，我们发现了 1124 篇论文，经过精炼过程后，有 13 项研究纳入了本荟萃分析。新冠病毒患者中肥胖的合并患病率为 29%（95%CI：14-47%）。对于糖尿病和高血压，这分别为 22%（95%CI：12%-33%）和 32%（95%CI：12%-56%）。这三个合并患病率的估计值存在显著异质性，但没有显著的小样本效应。这些警告点在某种程度上指导医生和临床医生更好地理解控制合并风险因素的重要性，以便在资源分配和干预措施中优先考虑。
荟萃分析表明，高血压在新冠病毒疾病患者中比肥胖和糖尿病更为普遍。必须采用合并代谢危险因素的患病率，以便更好地管理和确定公共卫生疫苗接种和其他必要干预措施的优先次序。这些结果可能有助于改善新冠病毒患者的服务提供，同时有助于制定更好的预防和应对新冠病毒及其关键结果的政策。
