新冠肺炎住院患者中高血压的患病率及相关风险：一项包含 1468 项研究和 1281510 例患者的 Meta 分析的 Meta 分析。

Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients.

机构信息

Center for the Development of Interdisciplinary Research in Islamic Sciences and Health Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Public Health Sciences, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.

出版信息

Syst Rev. 2022 Nov 17;11(1):242. doi: 10.1186/s13643-022-02111-2.

BACKGROUND

Since the COVID-19 outbreak, preliminary research has shown that some risk-associated conditions increase death and severe complications of the disease, hypertension being one of them. Thus, numerous meta-analyses have been conducted to explore this issue. Therefore, this umbrella review aims to perform a meta-analysis of the meta-analyses to estimate the prevalence and associated risks of hypertension in patients with COVID-19.

METHODS

PubMed, Scopus, Web of Knowledge, Embase, and Cochrane databases were searched for the published meta-analyses up to January 1, 2022. Google Scholar, citation check, reference check, and Grey literature were also manually searched. A random-effect model approach was used for analysis.

RESULTS

The overall death rate was estimated at 12%. Hypertension was present in 25% of the patients as a comorbid disease. The overall RR for death, disease severity, and the possibility of ICU admission were estimated at 1.79 [1.68-1.89 with 95% CI], 1.74 [1.66-1.83 with 95% CI], and 1.91 [1.48-2.34 with 95% CI], respectively. The meta-regression results showed that being "male" significantly increases the risk of disease severity and ICU admission.

CONCLUSIONS

The results indicated that hypertension is a common comorbid disease in hospitalized patients with COVID-19, which significantly increases mortality risk, the severity of the disease, and the probability of ICU admission.

SYSTEMATIC REVIEW REGISTRATION

This study has been registered in PROSPERO (CRD42021231844).

背景

自 COVID-19 爆发以来，初步研究表明，一些与风险相关的状况会增加死亡和疾病的严重并发症，高血压就是其中之一。因此，已经进行了许多荟萃分析来探讨这个问题。因此，本伞式综述旨在对荟萃分析进行荟萃分析，以估计 COVID-19 患者中高血压的患病率和相关风险。

方法

检索了 PubMed、Scopus、Web of Knowledge、Embase 和 Cochrane 数据库中截至 2022 年 1 月 1 日发表的荟萃分析。还手动搜索了 Google Scholar、引文检查、参考文献检查和灰色文献。使用随机效应模型方法进行分析。

结果

总体死亡率估计为 12%。高血压是 25%的患者的合并症。死亡、疾病严重程度和入住 ICU 的可能性的总体 RR 估计值分别为 1.79 [1.68-1.89，95%CI]、1.74 [1.66-1.83，95%CI]和 1.91 [1.48-2.34，95%CI]。荟萃回归结果表明，“男性”显著增加了疾病严重程度和 ICU 入院的风险。