Koneru P B, Lien E J, Koda R T
University of Southern California, School of Pharmacy, Los Angeles.
J Ocul Pharmacol. 1986 Fall;2(4):385-404. doi: 10.1089/jop.1986.2.385.
There have been many drugs reported to cause oculotoxic responses after their systemic administration. The severity of these toxicities range from minor ocular inconvenience to permanent loss of vision. This paper reviews the current literature and attempts to suggest some probable factors involved in the development of oculotoxicities by systemic drugs. Various drug entry and exit pathways in the eye are presented and the role of some intraocular structures in the toxicity development is examined. The issues of melanin binding, genetic heterogeneity, photosensitivity and environmental pollution are discussed.
据报道，许多药物在全身给药后会引起眼毒性反应。这些毒性的严重程度从轻微的眼部不适到永久性视力丧失不等。本文综述了当前的文献，并试图提出一些全身性药物导致眼毒性发生的可能因素。介绍了药物在眼内的各种进出途径，并研究了一些眼内结构在毒性发展中的作用。还讨论了黑色素结合、遗传异质性、光敏性和环境污染等问题。
