Association of Infection with the Development of Colorectal Cancer.

The role of () in the development of inflammatory bowel disease (IBD) and colitis-associated carcinogenesis (CAC) has seldom been investigated. We examined the abundance of in 58 colorectal cancers (CRCs), 20 IBDs, 40 cases of normal colorectal mucosa (NCs), and 20 adenomas (ADs) by 16S rRNA fluorescence in situ hybridization (FISH). Number of CD4CD45RBT cell and expression of IFN-γ and TNF-α in these tissues was determined by immunofluorescence. The abundance of was significantly higher in CRCs than that in IBDs (), ADs ( < 0.001) and NCs ( < 0.0001). The abundance of in IBDs was significantly higher than that in ADs (). Moreover, the average number of CD4CD45RBT cell was significantly higher in CRCs than that in IBDs () and NCs (). In addition, there was a positive correlation between the abundance and density of CD4CD45RBT cells in 30 colorectal tissues (). The frequency of co-staining for CD4CD45RBT cells and IFN-γ was significantly higher in positive group than that in negative group (). may play a role in the initiation of IBD and CAC, possibly through promoting the transformation of T cells into CD4CD45RBT cells and increasing the expression of proinflammatory cytokines IFN-γ.