解析免疫细胞复杂的基因调控。
Unravelling the complex genetic regulation of immune cells.
机构信息
Departments of Medicine and Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
出版信息
Nat Rev Rheumatol. 2021 Mar;17(3):131-132. doi: 10.1038/s41584-020-00563-1.
Abstract
Genetic variation contributes to immune cell function. An unprecedented analysis of genetic associations with immune cell traits provides insights into the complex regulation of immune cells, reveals variants that coincidently influence immune traits and autoimmune disease risk, and offers specific therapeutic targets for these diseases.
摘要
遗传变异有助于免疫细胞功能。对免疫细胞特征与遗传关联的空前分析提供了对免疫细胞复杂调控的深入了解，揭示了同时影响免疫特征和自身免疫性疾病风险的变异，并为这些疾病提供了特定的治疗靶点。
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