Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Departments of Population and Quantitative Health Sciences, and Genetics and Genome Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.
Cell. 2019 Mar 21;177(1):26-31. doi: 10.1016/j.cell.2019.02.048.
The majority of studies of genetic association with disease have been performed in Europeans. This European bias has important implications for risk prediction of diseases across global populations. In this commentary, we justify the need to study more diverse populations using both empirical examples and theoretical reasoning.
大多数与疾病相关的遗传关联研究都是在欧洲人群中进行的。这种欧洲人群的偏好对全球人群疾病风险预测有重要影响。在这篇评论中，我们将通过实证案例和理论推理来说明研究更多样化人群的必要性。
