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肽受体放射性核素治疗时代下神经内分泌肿瘤肝转移的肝靶向治疗

Liver-Directed Therapy for Neuroendocrine Tumor Liver Metastases in the Era of Peptide Receptor Radionuclide Therapy.

作者信息

Lehrman Evan D, Fidelman Nicholas

机构信息

Division of Interventional Radiology, Department of Radiology, University of California, San Francisco, California.

出版信息

Semin Intervent Radiol. 2020 Dec;37(5):499-507. doi: 10.1055/s-0040-1720951. Epub 2020 Dec 11.

DOI:10.1055/s-0040-1720951
PMID:33328706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7732556/
Abstract

Neuroendocrine tumor liver metastases are treated by a multidisciplinary cohort of physicians that work together to achieve optimal clinical results for their patients. This review addresses critical concepts in diagnosis and workup of such patients followed by medical, surgical, and liver-directed arterial and ablative therapies. Specific perioperative care for these patients is crucial in avoiding dreaded complications related to Carcinoid Crisis. The recent introduction of Peptide Receptor Radionuclide Therapy as a therapeutic option has impacted some of the algorithms for timing and selection of arterial embolotherapies.

摘要

神经内分泌肿瘤肝转移由多学科医生团队进行治疗,他们共同努力为患者实现最佳临床效果。本综述阐述了此类患者诊断和检查中的关键概念,随后介绍了药物、手术以及肝脏靶向动脉和消融治疗。对这些患者进行特定的围手术期护理对于避免类癌危象相关的可怕并发症至关重要。肽受体放射性核素治疗作为一种治疗选择的近期引入,对动脉栓塞治疗的时机选择和算法产生了一些影响。

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本文引用的文献

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Radioembolization-Induced Chronic Hepatotoxicity: A Single-Center Cohort Analysis.放射性栓塞诱导的慢性肝毒性:单中心队列分析。
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Long-Term Toxicity after Transarterial Radioembolization with Yttrium-90 Using Resin Microspheres for Neuroendocrine Tumor Liver Metastases.使用树脂微球进行钇-90经动脉放射性栓塞治疗神经内分泌肿瘤肝转移后的长期毒性
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Expanded criteria for debulking of liver metastasis also apply to pancreatic neuroendocrine tumors.扩大的肝转移瘤减瘤标准也适用于胰腺神经内分泌肿瘤。
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Dexamethasone Prophylaxis to Alleviate Postembolization Syndrome after Transarterial Chemoembolization for Hepatocellular Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled Study.地塞米松预防减轻肝细胞癌经动脉化疗栓塞术后栓塞后综合征:一项随机、双盲、安慰剂对照研究
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The Surgical Management of Small Bowel Neuroendocrine Tumors: Consensus Guidelines of the North American Neuroendocrine Tumor Society.小肠神经内分泌肿瘤的外科治疗:北美神经内分泌肿瘤学会共识指南
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