Tan Jiah Ning, Mohd Saffian Shamin, Buang Fhataheya, Jubri Zakiah, Jantan Ibrahim, Husain Khairana, Mohd Fauzi Norsyahida
Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Front Pharmacol. 2020 Nov 27;11:504624. doi: 10.3389/fphar.2020.504624. eCollection 2020.
species have been used traditionally to treat various ailments, such as fever, pain, and to control blood glucose level. This systematic review critically discusses studies regarding species that exhibited antioxidant and anti-inflammatory effects, thus providing perspectives and instructions for future research of the plants as a potential source of new dietary supplements or medicinal agents. A literature search from internet databases of PubMed, Scopus, Science Direct, e-theses Online Service, and ProQuest was carried out using a combination of keywords such as "," "antioxidant," "anti-inflammatory," or other related words. Research articles were included in this study if they were experimental ( and ) or clinical studies on the antioxidant or anti-inflammatory effects of species and if they were articles published in English. Altogether, 27 studies on antioxidant and anti-inflammatory effects of species were selected. The antioxidant effects of species were manifested by inhibition of reactive oxygen species production and lipid peroxidation, modulation of glutathione-related parameters, and enzymatic antioxidant production or activities. The anti-inflammatory effects of species were through the modulation of inflammatory cytokine production, inhibition of prostaglandin E and nitric oxide production, cellular inflammatory-related parameters, and inflammation in animal models. The potential anti-inflammatory signaling pathways modulated by species are glycogen synthase kinase-3, nuclear factor erythroid 2-related factor 2, PPARγ, MAPK, NF-κB, and PI3K/Akt. However, most reports on antioxidant and anti-inflammatory effects of the plants were on crude extracts, and the chemical constituents contributing to bioactivities were not clearly understood. There is a variation in quality of studies in terms of design, conduct, and interpretation, and in-depth studies on the underlying mechanisms involved in antioxidant and anti-inflammatory effects of the plants are in demand. Moreover, there is limited clinical study on antioxidant and anti-inflammatory effects of species. This review highlighted antioxidant and anti-inflammatory effects of genus and supported their traditional uses to treat oxidative stress and inflammatory-related diseases. This review is expected to catalyze further studies on genus . However, extensive preclinical data need to be generated from toxicity and pharmacokinetic studies before clinical studies can be pursued for their development into clinical medicines to treat oxidative stress and inflammatory conditions.
传统上，某些物种已被用于治疗各种疾病，如发烧、疼痛以及控制血糖水平。本系统综述批判性地讨论了有关具有抗氧化和抗炎作用的物种的研究，从而为将这些植物作为新的膳食补充剂或药物的潜在来源进行未来研究提供了观点和指导。使用诸如“[物种名称]”“抗氧化剂”“抗炎”或其他相关词汇的组合，在PubMed、Scopus、ScienceDirect、电子论文在线服务和ProQuest等互联网数据库中进行了文献检索。如果研究文章是关于[物种名称]物种抗氧化或抗炎作用的实验性（体内和体外）或临床研究，并且是以英文发表的文章，则纳入本研究。总共选择了27项关于[物种名称]物种抗氧化和抗炎作用的研究。[物种名称]物种的抗氧化作用表现为抑制活性氧的产生和脂质过氧化、调节谷胱甘肽相关参数以及酶促抗氧化剂的产生或活性。[物种名称]物种的抗炎作用是通过调节炎性细胞因子的产生、抑制前列腺素E和一氧化氮的产生、细胞炎症相关参数以及动物模型中的炎症来实现的。[物种名称]物种调节的潜在抗炎信号通路是糖原合酶激酶-3、核因子红细胞2相关因子2、PPARγ、MAPK、NF-κB和PI3K/Akt。然而，大多数关于这些植物抗氧化和抗炎作用的报道是关于粗提物的，对其生物活性的化学成分尚不清楚。在研究设计、实施和解释方面，研究质量存在差异，需要对这些植物抗氧化和抗炎作用的潜在机制进行深入研究。此外，关于[物种名称]物种抗氧化和抗炎作用的临床研究有限。本综述强调了[物种名称]属的抗氧化和抗炎作用，并支持其在治疗氧化应激和炎症相关疾病方面的传统用途。本综述有望促进对[物种名称]属的进一步研究。然而，在将其开发为治疗氧化应激和炎症病症的临床药物进行临床研究之前，需要从毒性和药代动力学研究中生成大量的临床前数据。
