Halula M C, Stocker B A
Department of Medical Microbiology, Stanford University School of Medicine, CA 93405.
Microb Pathog. 1987 Dec;3(6):455-9. doi: 10.1016/0882-4010(87)90015-5.
Presence or absence of mannose-resistant hemagglutination (MRHA) or sheep erythrocytes by Salmonella species was found to be consistent within most serotypes tested and did not correlate with O-antigen. Broad-host-range serotypes including S. typhimurium and S. enteritidis produced MRHA while host-specific serotypes including S. typhi, S. dublin, and S. gallinarum were MRHA-negative. MRHA produced by S. typhimurium was soluble, heat-stable, and not inhibited by any of eleven carbohydrates tested. Further investigation of MRHA may provide insight into mechanisms of Salmonella pathogenesis.
结果发现，在大多数测试血清型中，沙门氏菌对甘露糖抵抗性血凝反应（MRHA）或绵羊红细胞的呈现与否是一致的，且与O抗原无关。包括鼠伤寒沙门氏菌和肠炎沙门氏菌在内的广泛宿主范围血清型可产生MRHA，而包括伤寒沙门氏菌、都柏林沙门氏菌和鸡沙门氏菌在内的宿主特异性血清型则为MRHA阴性。鼠伤寒沙门氏菌产生的MRHA是可溶的、热稳定的，并且不受所测试的11种碳水化合物中任何一种的抑制。对MRHA的进一步研究可能有助于深入了解沙门氏菌的致病机制。
