Fitzgerald-Hayes M
Department of Biochemistry, University of Massachusetts, Amherst 01003.
Yeast. 1987 Sep;3(3):187-200. doi: 10.1002/yea.320030306.
Significant progress has been made toward understanding the roles played by conserved centromere DNA sequences in both mitotic and meiotic chromosome segregation. We are just beginning to formulate a picture of what a yeast kinetochore actually looks like and what components other than CEN DNA are necessary for function. In the next few years some of the genes encoding structural components of the kinetochore, and perhaps some involved in regulation of kinetochore function, will be cloned. Work is already in progress to isolate and characterize the proteins necessary for the assembly, maintenance and function of this amazing biological structure.
在理解保守的着丝粒DNA序列在有丝分裂和减数分裂染色体分离中所起的作用方面已经取得了重大进展。我们才刚刚开始描绘酵母动粒实际的样子，以及除CEN DNA之外还有哪些组件对于其功能是必需的。在未来几年中，一些编码动粒结构组件的基因，也许还有一些参与动粒功能调节的基因，将会被克隆出来。目前已经在开展工作，以分离和鉴定这种惊人的生物结构的组装、维持和功能所必需的蛋白质。
