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运用最优控制分析对2019冠状病毒的流行趋势进行建模。

Modeling the pandemic trend of 2019 Coronavirus with optimal control analysis.

作者信息

Fatima BiBi, Zaman Gul, Alqudah Manar A, Abdeljawad Thabet

机构信息

Department of Mathematics, University of Malakand, Chakdara Dir (Lower), Khyber Pakhtunkhawa, Pakistan.

Department of Mathematical Sciences, Faculty of Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.

出版信息

Results Phys. 2021 Jan;20:103660. doi: 10.1016/j.rinp.2020.103660. Epub 2020 Dec 9.

Abstract

In this work, we propose a mathematical model to analyze the outbreak of the Coronavirus disease (COVID-19). The proposed model portrays the multiple transmission pathways in the infection dynamics and stresses the role of the environmental reservoir in the transmission of the disease. The basic reproduction number is calculated from the model to assess the transmissibility of the COVID-19. We discuss sensitivity analysis to clarify the importance of epidemic parameters. The stability theory is used to discuss the local as well as the global properties of the proposed model. The problem is formulated as an optimal control one to minimize the number of infected people and keep the intervention cost as low as possible. Medical mask, isolation, treatment, detergent spray will be involved in the model as time dependent control variables. Finally, we present and discuss results by using numerical simulations.

摘要

在这项工作中,我们提出了一个数学模型来分析冠状病毒病(COVID-19)的爆发情况。所提出的模型描绘了感染动态中的多种传播途径,并强调了环境宿主在疾病传播中的作用。从该模型计算出基本再生数,以评估COVID-19的传播能力。我们进行敏感性分析以阐明流行参数的重要性。利用稳定性理论来讨论所提出模型的局部和全局性质。该问题被表述为一个最优控制问题,以尽量减少感染人数并使干预成本尽可能低。医用口罩、隔离、治疗、洗涤剂喷雾将作为随时间变化的控制变量纳入模型。最后,我们通过数值模拟展示并讨论结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/7728413/5cb712f479c7/gr1_lrg.jpg

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