Xu Gang, Liu Feng, Ye Min, Zhao Jun, Li Qing, Feng Congrui, Hu Yudong, Li Yueping, Shi Haiyan, Zhang Fuchun, Tong Yuwei, Ma Wei
Department of Geriatric Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Respiratory Medicine, Guangzhou Eighth People's Hospital, Guangzhou, China.
Front Med (Lausanne). 2020 Nov 30;7:593133. doi: 10.3389/fmed.2020.593133. eCollection 2020.
To clarify the clinical characteristics of cured patients with coronavirus disease (COVID-19), and to clarify the re-infection and person-to-person transmission in the cured. A total of 187 cured COVID-19 patients with antibody test were followed up every 2 weeks in this retrospective observational study. Assessment for general condition, symptoms, epidemiological contact history, polymerase chain reaction (PCR) assay, and antibody tests were performed and recorded. Information from Guangzhou CDC was also screened. There were 33 (17.6%) patients with negative results for IgG and 35 (18.7%) patients with positive results for IgM. The average days of antibody detection from disease onset were 53.0. PCR assay was positive in 10 (5.3%) patients during the follow-up. Neither IgG nor IgM results showed a relationship with PCR test results (all > 0.05). Neither re-infection nor person-to-person transmission was found in the cured patients. Factors associated with appearance of antibody comprised hospitalization days (OR: 1.06, 95%CI: 1.02-1.11, = 0.006) and antibiotics treatment (OR: 3.50, 95%CI: 1.40-8.77, = 0.007). In our study, no evidence of person-to-person transmission was found in cured COVID-19 patients. There seemed to be no re-infection in the cured COVID-19 patients in Guangzhou. These finding suggest that the cured do not cause the spread of disease. Additionally, neither IgG nor IgM can be used to replace the PCR test in cured patients.
为明确新型冠状病毒肺炎（COVID-19）治愈患者的临床特征，并明确治愈患者中的再感染及人际传播情况。在这项回顾性观察研究中，对187例接受抗体检测的COVID-19治愈患者每2周进行一次随访。进行并记录一般状况、症状、流行病学接触史、聚合酶链反应（PCR）检测及抗体检测的评估。还筛查了来自广州疾病预防控制中心的信息。33例（17.6%）患者IgG结果为阴性，35例（18.7%）患者IgM结果为阳性。从发病到抗体检测的平均天数为53.0天。随访期间10例（5.3%）患者PCR检测呈阳性。IgG和IgM结果均与PCR检测结果无关（均>0.05）。在治愈患者中未发现再感染及人际传播情况。与抗体出现相关的因素包括住院天数（OR：1.06，95%CI：1.02-1.11，P = 0.006）和抗生素治疗（OR：3.50，95%CI：1.40-8.77，P = 0.007）。在我们的研究中，未在COVID-19治愈患者中发现人际传播的证据。广州的COVID-19治愈患者似乎未出现再感染情况。这些发现表明，治愈患者不会导致疾病传播。此外，IgG和IgM均不能用于替代治愈患者的PCR检测。
