对严重急性呼吸综合征冠状病毒2感染的持续细胞免疫。
Persistent Cellular Immunity to SARS-CoV-2 Infection.
作者信息
Breton Gaëlle, Mendoza Pilar, Hagglof Thomas, Oliveira Thiago Y, Schaefer-Babajew Dennis, Gaebler Christian, Turroja Martina, Hurley Arlene, Caskey Marina, Nussenzweig Michel C
机构信息
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Hospital Program Direction, The Rockefeller University, New York, NY 10065, USA.
出版信息
bioRxiv. 2020 Dec 9:2020.12.08.416636. doi: 10.1101/2020.12.08.416636.
UNLABELLED
SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4 and CD8 T cells, expression of activation/exhaustion markers, and cell division.
SUMMARY
We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4 and CD8 T cells compartments.
未标记
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了一场正在全球范围内影响数百万人的大流行。为了进一步了解康复个体的免疫反应，我们测量了41名个体在感染后平均1.3个月和6.1个月获得的配对样本中的T细胞反应。数据表明，康复个体表现出持续的多功能SARS-CoV-2抗原特异性记忆，这可能有助于快速回忆反应。此外，康复个体在CD4和CD8 T细胞的相对数量、激活/耗竭标志物的表达以及细胞分裂方面表现出持久的免疫改变。
总结
我们表明，SARS-CoV-2感染引发了广泛反应性和高功能性的记忆T细胞反应，这些反应在感染后持续6个月。此外，康复个体在CD4和CD8 T细胞区室中表现出持久的免疫改变。
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