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季节性冠状病毒的保护免疫作用是短暂的。

Seasonal coronavirus protective immunity is short-lasting.

机构信息

Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

INGENASA, Inmunología y Genética Aplicada S. A., Madrid, Spain.

出版信息

Nat Med. 2020 Nov;26(11):1691-1693. doi: 10.1038/s41591-020-1083-1. Epub 2020 Sep 14.


DOI:10.1038/s41591-020-1083-1
PMID:32929268
Abstract

A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is the duration of acquired immunity. Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.

摘要

当前 2019 年冠状病毒病(COVID-19)大流行中一个未解决的关键问题是获得性免疫的持续时间。从感染四种季节性人类冠状病毒中获得的见解可能揭示适用于所有人类冠状病毒的共同特征。我们对健康个体进行了超过 35 年的监测,并确定在感染后 12 个月经常发生同种季节性冠状病毒的再感染。

相似文献

[1]
Seasonal coronavirus protective immunity is short-lasting.

Nat Med. 2020-9-14

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引用本文的文献

[1]
Challenges to the Effectiveness and Immunogenicity of COVID-19 Vaccines: A Narrative Review with a Systematic Approach.

Vaccines (Basel). 2025-7-24

[2]
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults.

Nat Commun. 2025-8-23

[3]
Leaky or polarised immunity: Non-Markovian modelling highlights the impact of immune memory assumptions.

PLoS Comput Biol. 2025-8-19

[4]
Clinical and immunological insights into SARS-CoV-2 reinfection: a propensity score-matched cohort study.

BMC Infect Dis. 2025-8-1

[5]
Dynamics of neutralizing antibodies against COVID-19 Omicron subvariants following breakthrough infection in southwest China between December 2022 and April 2024.

Signal Transduct Target Ther. 2025-7-30

[6]
Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic.

Front Public Health. 2025-7-2

[7]
'Vivaldi': an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2.

Microb Genom. 2025-7

[8]
Common Cold Coronavirus Test Positivity Decreased After Widespread SARS-CoV-2 Experience.

Open Forum Infect Dis. 2025-6-18

[9]
Untreated HIV-1 infection and low CD4+ T cell counts and their effect on endemic human coronavirus (re)infection.

PLOS Glob Public Health. 2025-6-18

[10]
Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection.

PLoS One. 2025-6-11

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