Laboratório de Fisiopatologia do Envelhecimento, Programa de Pós-Graduação em Saúde e Meio Ambiente, Universidade Metropolitana de Santos, Santos, SP, Brasil.
Departamento de Saúde I, Programa de Pós-Graduação em Educação Física UESB/UESC, Universidade Estadual do Sudoeste da Bahia, Jequié, BA, Brasil.
Braz J Med Biol Res. 2020 Dec 9;54(2):e10098. doi: 10.1590/1414-431X202010098. eCollection 2020.
We aimed to present an overview of the literature regarding the interaction between physical exercise and APOE gene polymorphism on cognitive function, particularly in patients with Alzheimer's disease (AD). Firstly, this review focused on the effect of the physical exercise on cognitive function, regardless of APOE gene polymorphism. Some studies have shown that a high level of cardiorespiratory fitness is associated with less neuronal damage with an improvement in memory score tests whereas other studies failed to detect any association between physical exercise and cognitive improvement either in healthy individuals or patients with AD. Taken together, standardized protocols and more longitudinal studies are required to provide a better insight into the effects of physical exercise on cognitive function. Although there is no agreement in the literature regarding the effects of physical exercise on cognitive function, it is well established that it improves social interaction and the feeling of well-being, thereby positively contributing to the quality of life of the elderly. Regarding the influence of physical exercise on cognitive function in APOE ε4 allele carriers, the data trend shows that the carriers of allele ε4 for APOE gene were more responsive to the beneficial effects of physical exercise on cognitive function compared with non-carriers. Nevertheless, studies with larger sample sizes will provide more accuracy about this relationship.
我们旨在概述关于体力活动与 APOE 基因多态性对认知功能相互作用的文献综述，特别是在阿尔茨海默病（AD）患者中。首先，本综述重点关注体力活动对认知功能的影响，而不考虑 APOE 基因多态性。一些研究表明，较高的心肺适应度与较少的神经元损伤相关，从而改善记忆评分测试，而其他研究未能检测到体力活动与认知改善之间的任何关联，无论是在健康个体还是 AD 患者中。总之，需要标准化的方案和更多的纵向研究来更深入地了解体力活动对认知功能的影响。尽管文献中对体力活动对认知功能的影响存在争议，但已明确的是，它可改善社交互动和幸福感，从而对老年人的生活质量产生积极影响。关于体力活动对 APOE ε4 等位基因携带者认知功能的影响，数据趋势表明，与非携带者相比，APOE 基因 ε4 等位基因携带者对体力活动对认知功能的有益影响更为敏感。然而，更大样本量的研究将提供更准确的关于这种关系的信息。
