Department of Pediatric Otolaryngology, Children's National Hospital, Washington, District of Columbia, U.S.A.
School of Medicine and Health Science, The George Washington University, Washington, District of Columbia, U.S.A.
Laryngoscope. 2021 Jul;131(7):1670-1675. doi: 10.1002/lary.29327. Epub 2020 Dec 17.
OBJECTIVE/HYPOTHESIS: Determine if the presentation of voice versus airway symptoms at the time of diagnosis of juvenile recurrent respiratory papillomatosis (JORRP) correlates with treatment and outcomes.
Original report, Retrospective review.
Twenty year retrospective review of all patients with JORRP presenting at any time in treatment to a single tertiary children's hospital between 1997 and 2017.
Fifty-four patients presented with a diagnosis of JORRP during the 20 year study period. Of these, 32 were female and 22 were male. African American children made up the majority of the patients (65%), with 19% identifying as Caucasian, 9% Hispanic, and 7% Asian. Fifteen of the children presented initially to the ENT clinic (87% with hoarseness), 12 to the emergency department (92% with airway concerns), 11 to the voice clinic, and the remaining 12 at outside hospitals or clinics and care were transferred. Voice symptoms, namely hoarseness, was the presenting symptom in 31 (57%), airway symptoms, namely respiratory distress or stridor was predominate in 17 (32%), and the presenting symptom was unknown in six cases (11%). Children presenting with airway symptoms were younger at presentation (median 2.1 years, range 0.38-8.77 years) than those presenting with voice symptoms (median 6.7 years, range 0.98-15.13 years), and after adjusting for age underwent a greater number of surgeries in the first year to control disease.
Patients who present with airway symptoms present younger and have an increased number of surgeries in the first year compared to those presenting with voice complaints.
4 Laryngoscope, 131:1670-1675, 2021.
目的/假设：确定青少年复发性呼吸道乳头状瘤病（JORRP）诊断时的声音与气道症状表现是否与治疗和结果相关。
原始报告，回顾性研究。
对 1997 年至 2017 年间在一家三级儿童医院接受治疗的任何时间出现 JORRP 的所有患者进行了 20 年的回顾性研究。
在 20 年的研究期间，54 名患者被诊断为 JORRP。其中，32 名女性，22 名男性。非裔美国人患儿占大多数（65%），19%为白种人，9%为西班牙裔，7%为亚洲人。15 名患儿最初就诊于耳鼻喉科诊所（87%有声音嘶哑），12 名患儿就诊于急诊室（92%有气道问题），11 名患儿就诊于语音诊所，其余 12 名患儿在其他医院或诊所就诊，随后转入本院。31 名（57%）患儿的首发症状为声音症状，即声音嘶哑，17 名（32%）患儿的首发症状为气道症状，即呼吸窘迫或喘鸣，6 名（11%）患儿的首发症状不明。出现气道症状的患儿发病时年龄较小（中位数 2.1 岁，范围 0.38-8.77 岁），比出现声音症状的患儿（中位数 6.7 岁，范围 0.98-15.13 岁）小，并且在调整年龄后，他们在第一年接受了更多的手术来控制疾病。
与出现声音症状的患者相比，出现气道症状的患者就诊年龄更小，且在第一年接受了更多的手术。
4 Laryngoscope, 131:1670-1675, 2021.
