Department of Otolaryngology Head and Neck Surgery. Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Beijing, China.
Western University of Health Sciences, Pomona, California, U.S.A.
Laryngoscope. 2021 Jul;131(7):EE2277-E2283. doi: 10.1002/lary.29376. Epub 2021 Jan 7.
To investigate the clinical characteristics and long-term outcomes of juvenile onset recurrent respiratory papillomatosis (JORRP) with or without pulmonary involvement.
A group of patients with JORRP who had clinical course over an extended period of time (at least 5 years) in the Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital were included in this retrospective study. Lung/bronchus involvement was revealed by lung imaging. Data on mortality rate, frequency of surgical interventions, and age of disease onset were collected and analyzed.
The 192 patients (107 male and 85 female) included had a median [quartiles] age of JORRP onset of 2 [1, 4] years, and median follow-up duration of 10 [7, 13] years; 17 patients (8.9%) had papilloma with bronchial and pulmonary involvement 7.0 [4.0, 12.5] years after the onset of the disease. Compared to patients without lung involvement, patients with lung involvement had a younger age of disease onset (P = .001), higher frequency of surgical interventions (P < .001), higher mortality rate (OR = 94.909), and an increased risk of tracheotomy that could not be decannulated (P < .001). They also had a younger age of disease onset, and a higher frequency of surgical interventions and mortality compared to patients with tracheotomy but free from lung involvement (P < .001).
Children with JORRP and with pulmonary involvement have a higher average number of operations per year than those without pulmonary involvement, and pulmonary involvement indicates a higher incidence of tracheotomy that cannot be decannulated.
4 Laryngoscope, 131:E2277-E2283, 2021.
研究伴有或不伴有肺部受累的青少年复发性呼吸道乳头瘤病（JORRP）的临床特征和长期转归。
本回顾性研究纳入了北京同仁医院耳鼻喉头颈外科长期（至少 5 年）接受治疗的一组 JORRP 患者。通过肺部成像显示肺部/支气管受累。收集并分析死亡率、手术干预频率和发病年龄等数据。
192 例患者（107 例男性和 85 例女性）的中位（四分位距）JORRP 发病年龄为 2 [1，4]岁，中位随访时间为 10 [7，13]年；17 例（8.9%）患者在疾病发病 7.0 [4.0，12.5]年后出现支气管和肺部乳头瘤病。与无肺部受累的患者相比，有肺部受累的患者发病年龄更小（P =.001），手术干预频率更高（P <.001），死亡率更高（OR = 94.909），且气管切开后无法拔管的风险更高（P <.001）。与有气管切开但无肺部受累的患者相比，有肺部受累的患者发病年龄更小，手术干预和死亡率更高（P <.001）。
伴有肺部受累的 JORRP 患儿每年的平均手术次数多于无肺部受累者，且肺部受累预示着气管切开后无法拔管的发生率更高。
4 级 喉镜，131：E2277-E2283，2021 年。
