Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Department of Otolaryngology-Head and Neck Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Clin Otolaryngol. 2021 Jan;46(1):161-167. doi: 10.1111/coa.13635. Epub 2020 Sep 17.
To investigate the adult outcomes of children with juvenile-onset recurrent respiratory papillomatosis via long-term follow-up.
Retrospective study.
Beijing Tongren Hospital.
The study includes 121 patients with recurrent respiratory papillomatosis.
We followed up respiratory papillomatosis patients aged least 14 years and analysed their clinical features based on recurrence-free time.
In total, 112 (92.6%) patients underwent three or more operations. The age at initial operation was 4.3 ± 2.9 years; 47.9% (58/121) experienced recurrence and underwent surgical treatment after age 14. At follow-up, 5% (6/121) had died, 41.3% (50/121) had been recurrence-free for 5 years or more (cured group), and 53.7% (65/121) had recurrence in the past 5 years (recurrent group). The age at the last operation was 9.2 ± 4.6 years in the cured group. The overall operation frequency was higher in the recurrence group than in the cured group (17.8 ± 11.9 vs 8.7 ± 6.5). Additionally, the human papillomavirus (HPV) infection and tracheal dissemination rates were higher in the recurrence group than in the cured group (90.8% [59/65] vs 54.0% [27/50] and 26.2% [17/65] vs 10% [5/50], respectively).
The mortality rate for juvenile-onset recurrent respiratory papillomatosis is 5%. Approximately 50% of children experience recurrence and require repeated operations in adulthood. No significant difference in sex, age at initial operation or adjuvant therapy between the cured and recurrent groups was observed; however, significant between-group differences were found in overall operation frequency, aggressive disease, tracheal dissemination of papilloma, and HPV infection.
通过长期随访，研究儿童期发病的复发性呼吸道乳头瘤病患者的成年结局。
回顾性研究。
北京同仁医院。
本研究共纳入 121 例复发性呼吸道乳头瘤病患者。
对无瘤生存时间≥14 岁的呼吸道乳头瘤病患者进行随访，并分析其临床特征。
112 例（92.6%）患者接受了 3 次或以上手术治疗。初次手术时年龄为 4.3±2.9 岁；47.9%（58/121）患者在 14 岁后复发并接受手术治疗。随访时，5%（6/121）患者死亡，53.7%（65/121）患者在过去 5 年内复发，41.3%（50/121）患者已治愈（无瘤生存 5 年以上）。治愈组患者末次手术年龄为 9.2±4.6 岁，复发组患者的总体手术次数多于治愈组（17.8±11.9 次比 8.7±6.5 次）。此外，复发组患者的 HPV 感染率和气管播散率均高于治愈组（90.8%[59/65]比 54.0%[27/50]和 26.2%[17/65]比 10%[5/50]）。
儿童期发病的复发性呼吸道乳头瘤病患者的死亡率为 5%。约 50%的患者在成年后复发，需要反复手术。治愈组和复发组患者在性别、初次手术年龄或辅助治疗方面无显著差异，但两组患者在总手术次数、侵袭性疾病、乳头瘤气管播散和 HPV 感染方面存在显著差异。
