Kingma Jurjen S, Frenay Irene M, Meinders Arend Jan, van Dijk Vincent F, Harmsze Ankie M
St. Antonius ziekenhuis, afd. Klinische Farmacie,Nieuwegein.
Contact: Jurjen S. Kingma (
Ned Tijdschr Geneeskd. 2020 Nov 12;164:D5306.
At a time when self-sufficiency and health are becoming increasingly important in society, the chances of intoxications with wild plants are increasing. Foxglove contains poisonous cardiac glycosides such as digoxin, digitoxin and gitoxin. The levels vary greatly and depend on the season and the location of the plants. The "non-digoxin" cardiac glycosides show a limited cross-reaction with the digoxin assay. This means that a low or therapeutic digoxin level does not rule out a severe foxglove intoxication. Due to the long half-life of the different cardiac glycosides, toxic symptoms can be persistent.
A 43-year-old woman arrived at the Emergency Department with persistent vomiting and specific ECG-abnormalities. The day before, she drunk a smoothie made from wild plants picked in the woods. Patient appeared to have mistaken foxglove for common sorrel.
In case of persistent gastrointestinal complaints with specific ECG abnormalities after ingestion of plant material, clinicians should be aware of a foxglove intoxication.
在一个自给自足和健康在社会中变得越来越重要的时代,野生植物中毒的几率正在增加。毛地黄含有洋地黄毒苷、地高辛和吉他洛辛等有毒强心苷。其含量差异很大,取决于植物的季节和生长地点。“非地高辛”强心苷与地高辛检测的交叉反应有限。这意味着低地高辛水平或治疗性地高辛水平并不能排除严重的毛地黄中毒。由于不同强心苷的半衰期较长,中毒症状可能会持续存在。
一名43岁女性因持续呕吐和特定心电图异常抵达急诊科。前一天,她喝了一杯用从树林里采摘的野生植物制成的奶昔。患者似乎误将毛地黄认作普通酢浆草。
在摄入植物材料后出现持续胃肠道不适并伴有特定心电图异常的情况下,临床医生应警惕毛地黄中毒。