Shevchenko Iu L, Stoĭko Iu M, Gudymovich V G, Cherniago T Iu
National Medical and Surgical Centre named after N.I. Pirogov under the RF Ministry of Public Health, Moscow, Russia.
Angiol Sosud Khir. 2020;26(4):71-77. doi: 10.33529/ANGIO2020404.
Modern vascular surgery has the data on a substantial role of the endothelium in pathogenesis of vascular diseases. Endothelial dysfunction is associated with a wide range of pathological processes including those in chronic diseases of lower-limb veins. The discovery of the endothelial glycocalyx made it possible to evaluate its role in the development of endothelial dysfunction as a trigger mechanism in impairment of venous blood flow. The understanding of the unifying role of endothelial dysfunction in pathology in various fields of medicine provides a possibility of predicting the development of serious socially significant diseases such as cardiovascular diseases, diabetes mellitus, obstetrical complications, and to correct the conditions associated therewith. The present study was aimed at carrying out a systematic literature review, thus making it possible to evaluate the role of the endothelial glycocalyx in the development of endothelial dysfunction, as well as to determine therapy with sulodexide capable of decreasing the probability of the onset of endothelial dysfunction at the expense of an anti-inflammatory, antithrombotic, and angioprotective effect on the endothelial wall.
现代血管外科拥有关于内皮细胞在血管疾病发病机制中重要作用的数据。内皮功能障碍与广泛的病理过程相关，包括下肢静脉慢性疾病中的病理过程。内皮糖萼的发现使得评估其在作为静脉血流受损触发机制的内皮功能障碍发展中的作用成为可能。理解内皮功能障碍在医学各个领域病理学中的统一作用，为预测心血管疾病、糖尿病、产科并发症等严重社会重大疾病的发展以及纠正与之相关的状况提供了可能性。本研究旨在进行系统的文献综述，从而能够评估内皮糖萼在内皮功能障碍发展中的作用，并确定舒洛地昔的治疗方法，该药物能够通过对内皮壁的抗炎、抗血栓和血管保护作用来降低内皮功能障碍发生的可能性。
