Yamaoka-Tojo Minako
Department of Rehabilitation/Regenerative Medicine and Cell Design Research Facility, Kitasato University School of Allied Health Sciences, Sagamihara 252-0373, Japan.
Department of Cardiovascular Medicine, Kitasato University Graduate School of Medical Sciences, Sagamihara 252-0373, Japan.
Int J Mol Sci. 2020 Dec 19;21(24):9712. doi: 10.3390/ijms21249712.
The new coronavirus disease-2019 (COVID-19), which is spreading around the world and threatening people, is easily infecting a large number of people through airborne droplets; moreover, patients with hypertension, diabetes, obesity, and cardiovascular disease are more likely to experience severe conditions. Vascular endothelial dysfunction has been suggested as a common feature of high-risk patients prone to severe COVID-19, and measurement of vascular endothelial function may be recommended for predicting severe conditions in high-risk patients with COVID-19. However, fragmented vascular endothelial glycocalyx (VEGLX) is elevated in COVID-19 patients, suggesting that it may be useful as a prognostic indicator. Although the relationship between VEGLX and severe acute respiratory syndrome coronavirus 2 infections has not been well studied, some investigations into COVID-19 have clarified the relationship between VEGLX and the mechanism that leads to severe conditions. Clarifying the usefulness of VEGLX assessment as a predictive indicator of the development of severe complications is important as a strategy for confronting pandemics caused by new viruses with a high affinity for the vascular endothelium that may recur in the future.
新型冠状病毒肺炎（COVID-19）正在全球蔓延并威胁着人们，它很容易通过空气飞沫感染大量人群；此外，高血压、糖尿病、肥胖症和心血管疾病患者更易出现重症情况。血管内皮功能障碍被认为是COVID-19重症高危患者的一个共同特征，对于预测COVID-19高危患者的重症情况，可能建议进行血管内皮功能检测。然而，COVID-19患者的破碎血管内皮糖萼（VEGLX）升高，这表明它可能作为一种预后指标。虽然VEGLX与严重急性呼吸综合征冠状病毒2感染之间的关系尚未得到充分研究，但对COVID-19的一些调查已经阐明了VEGLX与导致重症情况的机制之间的关系。明确VEGLX评估作为严重并发症发生预测指标的有用性，对于应对未来可能再次出现的、对血管内皮具有高亲和力的新型病毒引起的大流行而言，是一项重要策略。
