Department of Maxillo-Facial and Oral Surgery, Faculty of Dentistry and WHO Collaborating Centre, University of the Western Cape, Tygerberg Oral Health Center, Cape Town, South Africa.
PLoS One. 2020 Dec 17;15(12):e0244250. doi: 10.1371/journal.pone.0244250. eCollection 2020.
Residual cysts are relatively rare inflammatory cysts of the jaws. They are essentially radicular cysts without the presence of the offending dentition. These lesions have the ability to destroy bone within the jaws without any symptoms. Moreover, they can mimic more aggressive cysts and tumours on radiographs. The aim of this study was to describe the clinico-pathological features of residual cysts in order to discern them from other cystic lesions as well as analyse their management and recurrence patterns.
Sixty-four histopathologically confirmed residual cysts were analysed based on their clinical, radiological and histopathological features. Their management and follow-up were also noted.
The majority of lesions presented in elderly (46.8%), edentulous patients (60.9%) and were most commonly found in the posterior regions of the mandible (51.6%). Clinico-pathological features that aided in their diagnosis included long-standing history with slow growing swelling and presence of well-defined, unilocular cystic lesion associated with previously extracted dentition. Enucleation was a successful method in the management of residual cysts with very low recurrence rate (1.6%). Two patients (3.1%) developed squamous cell carcinoma from the cyst lining.
Residual cysts should be high on the list of differential diagnosis when elderly, edentulous patients present with cystic lesions in the jaws compared to dentate patients (P<0.01). All lesions should by biopsied and sent for histopathological examination along with radiological correlation as they have the potential to transform into primary intra-osseous squamous cell carcinoma with devastating consequences to the patient.
残余囊肿是颌骨中相对罕见的炎症性囊肿。它们本质上是没有致病牙齿的根尖囊肿。这些病变能够在没有任何症状的情况下破坏颌骨内的骨骼。此外,它们在影像学上可以模仿更具侵袭性的囊肿和肿瘤。本研究旨在描述残余囊肿的临床病理特征,以便将其与其他囊性病变区分开来,并分析其治疗和复发模式。
根据临床、影像学和组织病理学特征,对 64 例经组织病理学证实的残余囊肿进行分析。还记录了它们的治疗和随访情况。
大多数病变发生在老年人(46.8%)和无牙患者(60.9%)中,最常见于下颌后区(51.6%)。有助于诊断的临床病理特征包括病史长、生长缓慢的肿胀,以及存在界限清楚的单房囊性病变,与先前拔除的牙齿有关。囊内切除术是治疗残余囊肿的一种成功方法,复发率非常低(1.6%)。两名患者(3.1%)的囊肿内衬发生了鳞状细胞癌。
与有牙患者相比,当老年、无牙患者出现颌骨囊性病变时,残余囊肿应作为鉴别诊断的首要考虑因素(P<0.01)。所有病变都应进行活检,并进行组织病理学检查和影像学相关性检查,因为它们有可能转化为原发性骨内鳞状细胞癌,对患者造成灾难性后果。