依达赛珠单抗在逆转抗凝作用中的作用是什么？

What is the role of andexanet alfa in the reversal of anticoagulant effects?

机构信息

Jenna Hill Sewell is a pharmacy resident at the Gulf Coast Veterans Healthcare System in Biloxi, Miss. LaKeisha Williams is a clinical associate professor at Xavier University of Louisiana College of Pharmacy in New Orleans, La. Ellen McKnight is a community pharmacist at Walgreens Pharmacy in Memphis, Tenn. Anthony Nguyen is a clinical pharmacist at Ochsner Medical Center in New Orleans. Miroslav Sarac is an assistant professor at the Faculty of Pharmacy, Novi Sad, University Business Academy in Novi Sad, Serbia. The authors have disclosed no potential conflicts of interest, financial or otherwise.

出版信息

JAAPA. 2021 Jan 1;34(1):8-9. doi: 10.1097/01.JAA.0000723956.47623.90.

DOI:10.1097/01.JAA.0000723956.47623.90

PMID:33332828

Abstract

Although using direct oral anticoagulants increases patient risk for hemorrhagic events, FDA-approved options for reversing anticoagulant effects are limited. This article discusses one of the more recent FDA-approved antidotes, andexanet alfa, and provides guidelines for its safe and effective use.

摘要

虽然直接口服抗凝剂会增加患者出血事件的风险，但获得 FDA 批准的逆转抗凝效果的方法有限。本文讨论了最近获得 FDA 批准的一种解毒剂——andexanet alfa，并提供了其安全有效使用的指南。