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[异种小鼠辐射嵌合体造血器官的免疫荧光研究]

[Immunofluorescent study of the hemopoietic organs of xenogeneic mouse radiation chimeras].

作者信息

Vasil'eva T V, Tskhovrebova A Z, Michurina T V, Khrushchov N G

出版信息

Ontogenez. 1977;8(4):413-5.

PMID:333329
Abstract

An immunofluorescent study of hemopoietic organs in xenogenic (mouse-rat) radiation chimaeras has been carried out by means of specific antiserum against hemopoietic cells of the rat bone marrow. The presence of donor cells was tested at different times after the transplantation in the bone marrow, spleen, lymph nodes, thymus and liver of radiochimaeras. The transplanted cells were shown to populate all hemopoietic organs of the recipient, first of all tissues of the bone marrow type and, then, lymphoid organs. The donor (bone marrow) origin of the extramedullar foci of hemopoiesis in the liver was established.

摘要

利用针对大鼠骨髓造血细胞的特异性抗血清,对异种(小鼠-大鼠)辐射嵌合体的造血器官进行了免疫荧光研究。在移植后的不同时间,检测了放射性嵌合体的骨髓、脾脏、淋巴结、胸腺和肝脏中供体细胞的存在情况。结果显示,移植细胞定位于受体的所有造血器官,首先是骨髓型组织,然后是淋巴器官。确定了肝脏中髓外造血灶的供体(骨髓)来源。

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