Ferguson Emily J, Seigel Joel W, McGlory Chris
School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Curr Opin Clin Nutr Metab Care. 2021 Mar 1;24(2):114-119. doi: 10.1097/MCO.0000000000000723.
To examine recent findings related to the influence of omega-3 (ω-3) fatty acid supplementation on skeletal muscle anabolism with a particular focus on situations of skeletal muscle disuse.
Skeletal muscle disuse results in a reduction in fed and fasted rates of skeletal muscle protein synthesis leading to the loss of skeletal muscle mass. Recent evidence has suggested that supplementation with ω-3 fatty acids during a period of skeletal muscle disuse increases the ω-3 fatty acid composition of skeletal muscle membranes, heightens rates of skeletal muscle protein synthesis, and protects against skeletal muscle loss. The protective effects of ω-3 fatty acids towards skeletal muscle during disuse appear to be related to changes in mitochondrial bioenergetics suggesting crosstalk between mitochondria and the regulation of skeletal muscle protein synthesis.
ω-3 fatty acid ingestion is a potential preventive therapy to combat skeletal muscle-disuse atrophy but additional, appropriately powered randomized controlled trials are now needed in a range of populations before firm conclusions can be made.
探讨近期有关补充ω-3脂肪酸对骨骼肌合成代谢影响的研究结果，尤其关注骨骼肌废用的情况。
骨骼肌废用会导致骨骼肌蛋白质合成的进食和空腹速率降低，进而导致骨骼肌质量流失。最近的证据表明，在骨骼肌废用期间补充ω-3脂肪酸可增加骨骼肌膜的ω-3脂肪酸组成，提高骨骼肌蛋白质合成速率，并防止骨骼肌流失。ω-3脂肪酸在废用期间对骨骼肌的保护作用似乎与线粒体生物能量学的变化有关，这表明线粒体与骨骼肌蛋白质合成调节之间存在相互作用。
摄入ω-3脂肪酸是对抗骨骼肌废用性萎缩的一种潜在预防疗法，但在得出确切结论之前，现在需要在一系列人群中进行更多适当规模的随机对照试验。
