Student Research Committee, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.
Cytokine. 2021 Feb;138:155396. doi: 10.1016/j.cyto.2020.155396. Epub 2020 Dec 14.
Zinc (Zn) is a trace metal that is considered to have an impact on chronic inflammation. However, findings of clinical trials have been inconsistent. The present systematic review and meta-analysis aimed to provide a more robust examination of the evidence on the effectiveness of Zn supplements on markers of inflammation and oxidative stress.
A systematic search in PubMed, Scopus, Web of Science and Cochrane Library was undertaken to identify relevant randomized controlled trials (RCTs) assessing the impact of Zn on inflammation and oxidative stress until 17 August 2020. We applied a random-effects method to obtain effect sizes (ES) and 95% confidence intervals (CIs). Meta-regression was used to detect the potential source of between-study heterogeneity.
Twenty-one eligible RCTs comprising 1321 participants were included in the meta-analysis. In comparison with the control groups, serum C-reactive protein (CRP) (ES = -0.92 mg/L, 95% CI = [-1.36, -0.48], P < 0.001, I = 90.2%), tumor necrosis factor-alpha (TNF-α) (ES = -0.49 pg/mL, 95% CI = [-084, -0.14], P = 0.006, I = 34.6%) and malondialdehyde (MDA) (ES = -0.42, 95% CI = [-083, -0.01], P = 0.04, I = 76.1%) were significantly reduced in the groups receiving Zn. Serum interleukin 6 (ES = -1.02 pg/mL, 95% CI = [-2.06, 0.02], P = 0.05, I = 92.3%) was marginally reduced following Zn supplementation. Moreover, treatment duration was found as the source of inter-study heterogeneity.
This meta-analysis suggests that Zn supplements reduce serum concentrations of markers of inflammation and oxidation: CRP, TNF-α and MDA.
锌（Zn）是一种微量元素，据认为对慢性炎症有影响。然而，临床试验的结果并不一致。本系统评价和荟萃分析旨在更有力地检验 Zn 补充剂对炎症和氧化应激标志物的有效性的证据。
在 PubMed、Scopus、Web of Science 和 Cochrane Library 中进行系统检索，以确定截至 2020 年 8 月 17 日评估 Zn 对炎症和氧化应激影响的相关随机对照试验（RCT）。我们采用随机效应方法获得效应大小（ES）和 95%置信区间（CI）。采用元回归来检测研究间异质性的潜在来源。
共有 21 项符合条件的 RCT 纳入荟萃分析，共 1321 名参与者。与对照组相比，血清 C 反应蛋白（CRP）（ES=-0.92mg/L，95%CI=-1.36，-0.48，P<0.001，I=90.2%）、肿瘤坏死因子-α（TNF-α）（ES=-0.49pg/mL，95%CI=-0.84，-0.14，P=0.006，I=34.6%）和丙二醛（MDA）（ES=-0.42，95%CI=-0.83，-0.01，P=0.04，I=76.1%）显著降低。补充 Zn 后，血清白细胞介素 6（ES=-1.02pg/mL，95%CI=-2.06，0.02，P=0.05，I=92.3%）也略有降低。此外，研究间异质性的来源是治疗持续时间。
本荟萃分析表明，Zn 补充剂可降低炎症和氧化应激标志物的血清浓度：CRP、TNF-α 和 MDA。
