Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmacol Res. 2022 Dec;186:106484. doi: 10.1016/j.phrs.2022.106484. Epub 2022 Oct 4.
Vitamin D supplementation has attracted a lot of attention as a potential modulator of inflammation and oxidative stress, while some studies have reported controversial findings. In this regard, the purpose of this study was to summarize existing systematic reviews and meta-analyses of clinical trials that determined the effects of supplementation with vitamin D on inflammatory and oxidative biomarkers.
The following international databases were systematically searched till March 20th, 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. A random-effects model was applied to evaluate the effects of vitamin D on inflammatory and oxidative stress biomarkers.
Overall, 23 meta-analyses were qualified in this umbrella meta-analysis. Our findings revealed that the vitamin D supplementation significantly reduced serum C-reactive protein (CRP) (ES = -0.42; 95% CI: -0.55, -0.29, p < 0.001), tumor necrosis factor-α (TNF-α) (ES = -0.27; 95% CI: -0.42, -0.12; p < 0.001), and malondialdehyde (MDA) concentrations (ES = -0.37; 95% CI: -0.48, -0.25, p < 0.001). However, no significant changes were illustrated regarding interleukin-6 (IL-6) (ES = -0.35, 95% CI: -0.80, 0.10; p = 0.125), total antioxidant capacity (TAC) (ES = 0.68; 95% CI: -0.31, 1.66, p = 0.179), and glutathione (GSH) activity (ES = 0.08; 95% CI: -0.44, 0.60, p = 0.757).
The present umbrella meta-analysis indicated that supplementation of vitamin D in adults can improve CRP, TNF-α, and MDA levels under various health conditions. Vitamin D could be considered an adjuvant therapy for relieving inflammation and oxidative stress.
维生素 D 补充作为炎症和氧化应激的潜在调节剂受到了广泛关注，而一些研究的结果却存在争议。有鉴于此，本研究旨在总结现有的系统评价和荟萃分析临床试验，以确定维生素 D 补充对炎症和氧化生物标志物的影响。
系统检索了截至 2022 年 3 月 20 日的以下国际数据库：PubMed、Scopus、Embase、Web of Science 和 Google Scholar。应用随机效应模型评估维生素 D 对炎症和氧化应激生物标志物的影响。
总体而言，这项伞式荟萃分析共纳入了 23 项荟萃分析。我们的研究结果表明，维生素 D 补充显著降低了血清 C 反应蛋白（CRP）（ES = -0.42；95%CI：-0.55，-0.29，p<0.001）、肿瘤坏死因子-α（TNF-α）（ES = -0.27；95%CI：-0.42，-0.12；p<0.001）和丙二醛（MDA）浓度（ES = -0.37；95%CI：-0.48，-0.25，p<0.001）。然而，白细胞介素-6（IL-6）（ES = -0.35，95%CI：-0.80，0.10；p=0.125）、总抗氧化能力（TAC）（ES = 0.68；95%CI：-0.31，1.66，p=0.179）和谷胱甘肽（GSH）活性（ES = 0.08；95%CI：-0.44，0.60，p=0.757）无显著变化。
本伞式荟萃分析表明，在各种健康状况下，成年人补充维生素 D 可以改善 CRP、TNF-α 和 MDA 水平。维生素 D 可以被视为缓解炎症和氧化应激的辅助治疗药物。
