基于阿尔及利亚肿瘤学家和乳腺科医生的诊断数据的女性乳腺癌流行病学。

Epidemiology of breast cancer in women based on diagnosis data from oncologists and senologists in Algeria.

机构信息

Université Blida 1, Laboratoire de Cancérologie, Faculté de médecine, BP 270, Route de Soumaa Blida 9000, Algeria.

出版信息

Cancer Treat Res Commun. 2020;25:100220. doi: 10.1016/j.ctarc.2020.100220. Epub 2020 Oct 10.

DOI:10.1016/j.ctarc.2020.100220

PMID:33333411

Abstract

BACKGROUND

Breast cancer (BC) is a major health issue threatening women's life. No reliable epidemiological data on BC diagnosed by oncologists/senologists are available in Algeria.

METHODS

The BreCaReAl study, a non-interventional prospective cohort study, included adult women with confirmed BC in Algeria. Disease incidence, patients and disease characteristics, treatment patterns, and mortality rate were recorded up to 12 months of follow-up.

RESULTS

Overall, 1,437 patients were analysed: median age was 48 [41;57] years and 337 (23.5%) women had a family history of BC. BC incidence was 22.3 (95% CI: 21.5; 23.2) cases per 100,000 inhabitants over 8 months. Delayed diagnosis was reported in 400 (29.2%) patients. First line of treatments were mainly chemotherapy and surgery. Twenty-eight serious adverse events were reported including 10 (37.0%) events which led to death. Mortality rate reached 3.2% at 12 months CONCLUSION: A delayed diagnosis highlights the importance of implementing more effective screening strategies.

摘要

背景

乳腺癌（BC）是威胁女性生命的重大健康问题。在阿尔及利亚，没有关于肿瘤学家/老年病学家诊断的 BC 的可靠流行病学数据。

方法

BreCaReAl 研究是一项非干预性前瞻性队列研究，纳入了在阿尔及利亚确诊为 BC 的成年女性患者。记录了疾病发病率、患者和疾病特征、治疗模式以及 12 个月随访期间的死亡率。

结果

共分析了 1437 例患者：中位年龄为 48 [41；57] 岁，337 名（23.5%）女性有 BC 家族史。8 个月期间，BC 的发病率为 22.3（95%CI：21.5；23.2）/100,000 居民。报告了 400 例（29.2%）延迟诊断的病例。一线治疗主要是化疗和手术。报告了 28 例严重不良事件，包括 10 例（37.0%）导致死亡的事件。12 个月时死亡率达到 3.2%。