Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
BMC Surg. 2021 Oct 20;21(1):371. doi: 10.1186/s12893-021-01374-1.
Modified radical mastectomy is the procedure of choice in centers with little to no radiotherapy services. Studying the in-hospital outcome and complications associated with the procedure is important in low-income countries.
This is a multi-center prospective observational study involving all patients operated with modified radical mastectomy with curative intent.
A total of 87 patients were studied with 10.3% of which were male and 54% were between the age of 30-49 years. Clinical stage IIB and IIIA were reported in 33 (37.9%) and 25 (28.7%) respectively and 62.1% had clinically positive lymph nodes at presentation. All of the studied patients underwent curative surgery, with an average lymph node dissection of 10.2 ± 0.83. Seroma rate was 17.2% and was significantly associated with diabetes (AOR: 6.2 (CI 1.5-8.7)) and neoadjuvant chemotherapy (AOR: 8.9 (CI 1.2-14.2)). Surgical site infection occurred in 14.9% and was significantly associated with Retroviral infections (AOR: 4.2 (CI 2.1-5.8)) and neoadjuvant chemotherapy (AOR: 1.8 (CI 1.3-3.9)). No in-hospital mortality occurred during the course of the study.
Seroma rate was lower than published studies while surgical site infections rate was higher. Neoadjuvant chemotherapy was associated with increase in seroma and surgical site infection rates. Additionally, diabetes increased the rate of seroma. Surgical site infections were higher in patients with retroviral infections.
在缺乏放疗服务的中心，改良根治性乳房切除术是首选的手术方法。研究与该手术相关的住院期间结果和并发症对于低收入国家非常重要。
这是一项多中心前瞻性观察研究，涉及所有接受改良根治性乳房切除术的患者，这些患者均为治愈性手术。
共研究了 87 例患者，其中 10.3%为男性，54%年龄在 30-49 岁之间。报告的临床 IIB 期和 IIIA 期分别为 33 例（37.9%）和 25 例（28.7%），62.1%的患者在就诊时存在临床阳性淋巴结。所有研究患者均接受了治愈性手术，平均淋巴结清扫 10.2±0.83 个。血清肿发生率为 17.2%，与糖尿病（AOR：6.2（CI 1.5-8.7））和新辅助化疗（AOR：8.9（CI 1.2-14.2））显著相关。发生手术部位感染的患者有 14.9%，与逆转录病毒感染（AOR：4.2（CI 2.1-5.8））和新辅助化疗（AOR：1.8（CI 1.3-3.9））显著相关。研究过程中无院内死亡发生。
血清肿发生率低于已发表的研究，而手术部位感染率较高。新辅助化疗与血清肿和手术部位感染发生率的增加相关。此外，糖尿病增加了血清肿的发生率。存在逆转录病毒感染的患者手术部位感染发生率更高。
