Luo Ziping, Luo Wenkun, Yi Qun
Department of Traditional Chinese Medicine, Hengyang No.1 People's Hospital, Hengyang, China.
School of Chemistry and Pharmaceutical Engineering, Changsha University of Science and Technology, Changsha, China.
Medicine (Baltimore). 2025 Aug 8;104(32):e43841. doi: 10.1097/MD.0000000000043841.
Sleep disorder is essentially a huge threat to both physiological and psychological health of human being, especially elderly, and population aging has exacerbated the situation. Hypnotics are effective therapy for sleep disorder, while side-effects are frequently observed after long-term medication of hypnotics. The effects of opening and closing six-qi acupuncture (OCSQA) as an adjuvant therapy of hypnotics (i.e., Estazolam) treatment for sleep disorder of elderly were explored based on the Pittsburgh sleep quality index scores, the traditional Chinese medicine syndrome scores, the serum levels of immunoglobulins (IgG, IgA, and IgM) and the overall efficacy. Hypnotics could effectively relieve sleep disorder of elderly; OCSQA had positive impacts on the relief of sleep disorder by hypnotics, and can relieve side-effects (e.g., anxiety, ataxia) induced by medication of hypnotics. Additionally, no significant adverse events were reported. OCSQA is an effective and safe adjuvant therapy for sleep disorder of elderly due to therapeutic benefits on treatment with hypnotics.
睡眠障碍本质上对人类尤其是老年人的生理和心理健康构成巨大威胁，而人口老龄化加剧了这种情况。催眠药是治疗睡眠障碍的有效疗法，但长期服用催眠药后副作用屡见不鲜。基于匹兹堡睡眠质量指数评分、中医证候评分、免疫球蛋白（IgG、IgA和IgM）血清水平及总体疗效，探讨了开合六气针法作为催眠药（即艾司唑仑）辅助疗法治疗老年睡眠障碍的效果。催眠药可有效缓解老年人的睡眠障碍；开合六气针法对催眠药缓解睡眠障碍有积极作用，且可减轻催眠药用药引起的副作用（如焦虑、共济失调）。此外，未报告明显不良事件。由于对催眠药治疗有辅助治疗作用，开合六气针法是治疗老年睡眠障碍的一种有效且安全的辅助疗法。
