Division of Neuroscience, Department of Psychiatry, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Tsu, Japan.
Division of Neuroscience, Department of Psychiatry, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Tsu, Japan,
Neuropsychobiology. 2021;80(4):333-341. doi: 10.1159/000512699. Epub 2020 Dec 17.
Panic disorder (PD) has many comorbidities such as depression, bipolar disorder (BPD), and agoraphobia (AG). PD is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Recently, a tri-allelic serotonin transporter (5-HTTLPR/rs25531) polymorphism was reported to be more sensitive to personality traits compared to the bi-allelic 5-HTTLPR polymorphism. We hypothesized that the 5-HTTLPR/rs25531 polymorphism may lead to a pathological anxious state depending on the presence or absence of a comorbidity in PD.
In this study, we investigated the relationship between comorbidities in PD and tri-allelic 5-HTTLPR polymorphisms. A total of 515 patients with PD (148 males, 367 females) were genotyped, and the Revised NEO Personality Inventory as well as anxiety-related psychological tests were administered. Depression, BPD, and AG were diagnosed as comorbidities.
For the tri-allele 5-HTTLPR genotype, a significant interaction effect was found between openness to experience and comorbid depression. Examination of the interaction between AG and the tri-allelic 5-HTTLPR genotype revealed that L' allele carriers are associated with higher trait anxiety than the S'S' genotype group in PD without AG.
Some anxiety and personality traits can be characterized by the tri-allelic gene effect of 5-HTTLPR. These results suggest that tri-allelic 5-HTTLPR genotypes have genetic effects on the presence of comorbidities of PD.
恐慌障碍（PD）有许多合并症，如抑郁症、双相情感障碍（BPD）和广场恐惧症（AG）。PD 是一种中度遗传的焦虑障碍，其发病机制尚不清楚。最近，有人报告三等位体 5-羟色胺转运体（5-HTTLPR/rs25531）多态性比双等位体 5-HTTLPR 多态性更敏感于人格特质。我们假设，5-HTTLPR/rs25531 多态性可能导致 PD 患者出现病理焦虑状态，具体取决于是否存在合并症。
在这项研究中，我们研究了 PD 合并症与三等位体 5-HTTLPR 多态性之间的关系。对 515 名 PD 患者（男性 148 名，女性 367 名）进行了基因分型，并进行了修订的 NEO 人格量表以及焦虑相关的心理测试。抑郁症、BPD 和 AG 被诊断为合并症。
对于三等位体 5-HTTLPR 基因型，开放性与合并抑郁症之间存在显著的交互作用效应。对 AG 与三等位体 5-HTTLPR 基因型之间的交互作用的检查表明，在无 AG 的 PD 患者中，L'等位基因携带者的特质焦虑水平高于 S'S'基因型组。
一些焦虑和人格特质可以通过 5-HTTLPR 的三等位体基因效应来描述。这些结果表明，三等位体 5-HTTLPR 基因型对 PD 合并症的存在具有遗传效应。
