Department of Psychiatry, Fourth Hospital of Wuhu City, Wuhu, Anhui, China.
Department of Psychiatry, Shenyang Mental Health Center, Shenyang, Liaoning, China.
Aging (Albany NY). 2024 Aug 28;16(17):12293-12311. doi: 10.18632/aging.206087.
HTR1A C-1019G polymorphism (rs6295) and serotonin transporter promoter polymorphism (5-HTTLPR) have been linked with panic disorder (PD) in different ethnic backgrounds. Both these polymorphisms are in the promoter regions. However, results are inconsistent and contrasting evidence makes reliable conclusions even more challenging. A meta-analysis was conducted to test whether C-1019G polymorphism and 5-HTTLPR were involved in the etiology of PD. Articles researching the link between C-1019G, 5-HTTLPR polymorphisms, and PD were retrieved by database searching and systematically selected on the basis of selected inclusion parameters. 21 studies were included that examined the relationship of rs6295,5-HTTLPR polymorphisms with PD risk susceptibility (rs62957 polymorphism - 7 articles, and 5-HTTLPR polymorphism - 14 articles). A significant association was seen between the rs6295 polymorphism and PD pathogenesis, especially in Caucasian PD patients. No significant genetic linkage was found between the 5-HTTLPR polymorphism and PD. C-1019G polymorphism was involved in the etiology of PD in Caucasian patients. The 5-HTTLPR polymorphism was not a susceptibility factor of PD.
HTR1A C-1019G 多态性（rs6295）和 5-羟色胺转运体启动子多态性（5-HTTLPR）与不同种族背景的惊恐障碍（PD）有关。这两种多态性都位于启动子区域。然而，结果并不一致，相互矛盾的证据使得得出可靠的结论更加具有挑战性。进行了一项荟萃分析，以检验 C-1019G 多态性和 5-HTTLPR 是否与 PD 的病因有关。通过数据库搜索检索研究 C-1019G、5-HTTLPR 多态性与 PD 之间关系的文章，并根据选定的纳入参数进行系统选择。共纳入 21 项研究，这些研究检查了 rs6295、5-HTTLPR 多态性与 PD 风险易感性（rs62957 多态性-7 项研究，5-HTTLPR 多态性-14 项研究）之间的关系。rs6295 多态性与 PD 发病机制之间存在显著关联，尤其是在白种人 PD 患者中。5-HTTLPR 多态性与 PD 之间未发现明显的遗传连锁。C-1019G 多态性参与了白种人 PD 患者的发病机制。5-HTTLPR 多态性不是 PD 的易感因素。
