Li Z L, Zhang Y Q, Zhang Q, Ma C W, Zhao M, Xi B
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University/Children Cardiovascular Research Center of Shandong University, Ji'nan 250012, China.
Department of Food Nutrition and Child Health Care, Zibo Center for Diseases Prevention and Control, Zibo 255026, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Dec 6;54(12):1389-1395. doi: 10.3760/cma.j.cn112150-20200610-00853.
To examine the association between dairy intake frequency and left ventricular hypertrophy(LVH) in childhood. Data were obtained from Huantai Childhood Cardiovascular Health Cohort study in Huantai County, Zibo City, Shandong Province. A convenient cluster sampling method was used to conduct a baseline survey on 1 515 children aged 6-11 years old in a primary school from November 2017 to January 2018. A total of 1 237 children who had complete data on questionnaire, physical, ultrasound and laboratory examinations were included for analysis. The frequency of dairy intake was divided into five groups (never,≤3 times/month, 1-2 times/week, 3-5 times/week and nearly every day). Multivariate linear regression models and chi-square trend test were used to examine the trend in level of LVMI and prevalence of LVH, respectively. With the increase of dairy intake frequency, and multivariate logistic regression models were used to evaluate the association between dairy intake frequencies and LVH in childhood. The age of children was (8.4±1.6) years, and the number of boys was 655 (53.0%). There was no significant difference in LVMI levels among different frequencies of dairy intake (>0.05). With the increase of dairy intake frequencies, the level of LVMI and the prevalence of LVH decreased significantly ( for trend<0.05). After the adjustment of potential covariates, compared with no dairy intake group, children who consumed dairy products 1-2 times/week (=0.27, 95%:0.09-0.82), 3-5 times/week (=0.33, 95%:0.12-0.91) and almost every day (=0.22, 95%:0.09-0.54) had a lower risk of LVH. Dairy intake frequency is associated with LVH in childhood, and children who consume dairy products frequently (more than once a week) are less likely to have LVH.
探讨儿童期乳制品摄入频率与左心室肥厚（LVH）之间的关联。数据来自山东省淄博市桓台县的桓台儿童心血管健康队列研究。2017年11月至2018年1月，采用方便整群抽样方法，对某小学1515名6-11岁儿童进行了基线调查。共纳入1237名在问卷、体格检查、超声及实验室检查方面有完整数据的儿童进行分析。乳制品摄入频率分为五组（从不、≤每月3次、每周1-2次、每周3-5次和几乎每天）。分别采用多变量线性回归模型和卡方趋势检验来研究左心室质量指数（LVMI）水平的趋势和LVH的患病率。随着乳制品摄入频率的增加，采用多变量逻辑回归模型来评估儿童期乳制品摄入频率与LVH之间的关联。儿童年龄为（8.4±1.6）岁，男孩655名（53.0%）。不同乳制品摄入频率组间LVMI水平差异无统计学意义（>0.05）。随着乳制品摄入频率的增加，LVMI水平和LVH患病率显著降低（趋势<0.05）。在调整潜在协变量后，与不摄入乳制品组相比，每周摄入1-2次乳制品的儿童（比值比=0.27，95%可信区间：0.09-0.82）、每周摄入3-5次乳制品的儿童（比值比=0.33，95%可信区间：0.12-0.91）和几乎每天摄入乳制品的儿童（比值比=0.22，95%可信区间：0.09-0.54）发生LVH的风险较低。儿童期乳制品摄入频率与LVH有关，经常（每周超过一次）摄入乳制品的儿童发生LVH的可能性较小。
