Gregory C R, Gourley I M, Taylor N J, Broaddus T W, Olds R B, Patz J D
Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.
J Vet Intern Med. 1987 Apr-Jun;1(2):53-60. doi: 10.1111/j.1939-1676.1987.tb01987.x.
Renal allograft transplantation was performed as treatment for terminal renal failure in six veterinary patients. Three patients failed to survive the postsurgical period, one patient died due to acute allograft rejection, one patient died subsequent to complications of previous parenteral hyperalimentation and infection, and one patient was euthanatized due to the inability of the clients to maintain the effort necessary to manage a transplant recipient. Further clinical studies are necessary to determine if renal transplantation with cyclosporine (cyclosporin A)/prednisolone immunosuppression has the potential to provide practical treatment of terminal renal disease in clinical veterinary medicine. Pharmacologic and immunologic monitoring of transplant recipients with individualized immunosuppression is imperative. Careful surveillance is necessary to identify and eliminate nosocomial sources of infection. Candidates for transplantation cannot be critically ill or malnourished prior to surgery, and pet owners must be prepared for the financial and time commitments associated with caring for a renal allograft recipient.
对六只患有终末期肾衰竭的兽医临床病例进行了同种异体肾移植手术。三只动物未能存活至术后阶段，一只动物死于急性移植排斥反应，一只动物因先前胃肠外高营养和感染的并发症而死亡，还有一只动物因主人无力维持管理移植受体所需的努力而实施安乐死。有必要进行进一步的临床研究，以确定环孢素（环孢菌素A）/泼尼松龙免疫抑制的肾移植是否有潜力在临床兽医学中为终末期肾病提供切实可行的治疗方法。对接受个体化免疫抑制的移植受体进行药理和免疫监测至关重要。必须进行仔细监测以识别和消除医院感染源。移植候选动物在手术前不能病情危急或营养不良，宠物主人必须为照顾同种异体肾移植受体所涉及的经济和时间投入做好准备。
