Németh T, Tóth J, Balogh L, Jánoki G, Manczur F, Vörös K, Dallos G
Clinic of Surgery and Ophthalmology, University of Veterinary Science, Budapest, Hungary.
Acta Vet Hung. 1998;46(2):295-303.
A case of successful renal allograft transplantation performed in a two-year-old female Dalmatian dog suffering from end-stage chronic renal failure is reported. A one-year-old male German shepherd with severely injured spinal cord was used as kidney donor. Simultaneous kidney allograft transplantation combined with hypothermic initial perfusion as graft conservation was done, placing the donor kidney into the right iliac fossa of the recipient. The immunosuppression protocol consisted of prednisolone and azathioprine. Regular physical, laboratory, ultrasonographic and scintigraphic examinations were used for assessing both the morphology and the function of the allograft. After a two-week period of hospitalisation the patient was discharged in a remarkably improving condition. The recipient died on postoperative day 45 of respiratory insufficiency resulting from secondary pneumonia and pulmonary oedema. Neither macroscopic nor microscopic abnormalities of the allograft were revealed by necropsy.
报道了一例在一只患有终末期慢性肾衰竭的两岁雌性斑点犬身上成功进行肾移植的病例。一只脊髓严重受损的一岁雄性德国牧羊犬被用作肾脏供体。进行了同种异体肾移植并结合低温初始灌注作为移植物保存方法，将供体肾脏置于受体的右髂窝。免疫抑制方案包括泼尼松龙和硫唑嘌呤。定期进行体格检查、实验室检查、超声检查和闪烁扫描检查以评估同种异体移植物的形态和功能。经过两周的住院治疗，患者出院时病情明显好转。受体在术后第45天死于继发性肺炎和肺水肿导致的呼吸功能不全。尸检未发现同种异体移植物有宏观或微观异常。
