Infectious Diseases Department, First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Integrated Chinese and Western Medicine Department, the Infectious Diseases Hospital of Changchun City, Changchun, 130123, Jilin, China.
BMC Infect Dis. 2020 Dec 17;20(1):961. doi: 10.1186/s12879-020-05677-1.
The clinical characteristics of patients with confirmed 2019 novel coronavirus disease (COVID-19) in Jilin Province, China were investigated.
Clinical, laboratory, radiology, and treatment data of 41 hospitalized patients with confirmed COVID-19 were retrospectively collected. The population was stratified by disease severity as mild, moderate, or severe, based on guidelines of the National Health and Medical Commission of China.
The 41 hospitalized patients with COVID-19 were studied, and the median age was 45 years (interquartile range [IQR], 31-53; range, 10-87 years) and 18 patients (43.9%) were female. All of the patients had recently visited Wuhan or other places (ie, Beijing, Thailand) or had Wuhan-related exposure. Common symptoms included fever (32[78%]) and cough (29[70.7%]). All patients were without hepatitis B/C virus hepatitis. CRP (C-reactive protein, 11.3 mg/L [interquartile range {IQR}, 2.45-35.2]) was elevated in 22 patients (53.7%), and cardiac troponin I (1.5 ng/mL [IQR, 0.8-5.0]) was elevated in 41 patients (100%). Chest computed tomographic scans showed bilateral ground glass opacity (GGO) or GGO with consolidation in the lungs of 27(65.9%) patients. 31(75.6%) patients had an abnormal electrocardiograph (ECG). Comparing the three groups, the levels of CRP and cardiac troponin I, GGO distribution in bilateral lungs, and electrocardiogram changes were statistically significant (p < 0.05). Cardiac troponin I had a strong positive correlation with CRP (r = 0.704, p = 0.042) and LDH (r = 0.738, p = 0.037).
Significant differences among the groups suggest that several clinical parameters may serve as biomarkers of COVID-19 severity at hospital admission. Elevated cTnI could be considered as a predictor of severe COVID-19, reflecting the prognosis of patients with severe COVID-19. The results warrant further inspection and confirmation.
对中国吉林省已确诊的 2019 年新型冠状病毒病（COVID-19）患者的临床特征进行了调查。
回顾性收集了 41 例确诊 COVID-19 住院患者的临床、实验室、影像学和治疗数据。根据中国国家卫生健康委员会的指南，根据疾病严重程度将人群分为轻症、中度或重症。
研究了 41 例 COVID-19 住院患者，中位年龄为 45 岁（四分位距 [IQR]，31-53；范围，10-87 岁），18 例（43.9%）为女性。所有患者均有近期武汉或其他地方（如北京、泰国）旅行史或与武汉有关的接触史。常见症状包括发热（32[78%]）和咳嗽（29[70.7%]）。所有患者均无乙型/丙型肝炎病毒肝炎。22 例（53.7%）患者 C 反应蛋白（CRP）升高（11.3mg/L[IQR，2.45-35.2]），41 例（100%）患者心肌肌钙蛋白 I（cTnI）升高（1.5ng/mL[IQR，0.8-5.0]）。胸部计算机断层扫描显示 27 例（65.9%）患者肺部双侧磨玻璃影（GGO）或 GGO 伴实变。31 例（75.6%）患者心电图（ECG）异常。比较三组患者，CRP 和 cTnI 水平、双肺 GGO 分布及心电图改变均有统计学意义（p<0.05）。cTnI 与 CRP（r=0.704，p=0.042）和 LDH（r=0.738，p=0.037）呈强正相关。
各组之间的显著差异表明，一些临床参数可能是住院时 COVID-19 严重程度的生物标志物。cTnI 升高可视为 COVID-19 严重程度的预测指标，反映了重症 COVID-19 患者的预后。结果有待进一步检查和确认。
