Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
CLinic for Children and Adolescents, Division for Neonatology, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
Pediatr Neonatol. 2021 Jan;62(1):11-20. doi: 10.1016/j.pedneo.2020.10.001. Epub 2020 Oct 24.
Characterization of neonates born to mothers with SARS-CoV-2 infection has been partially carried out. There has been no systematic review providing a holistic neonatal presentation including possible vertical transmission. A systematic literature search was performed using PubMed, Google Scholar and Web of Science up to June, 6 2020. Studies on neonates born to mothers with SARS-CoV-2 infection were included. A binary random effect model was used for prevalence and 95% confidence interval. 32 studies involving 261 neonates were included in meta-analysis. Most neonates born to infected mothers did not show any clinical abnormalities (80.4%). Clinical features were dyspnea in 11 (42.3%) and fever in 9 newborns (19.1%). Of 261 neonates, 120 neonates were tested for infection, of whom 12 (10.0%) tested positive. Swabs from placenta, cord blood and vaginal secretion were negative. Neonates are mostly non affected by the mother's SARS-CoV-2 infection. The risk of vertical transmission is low.
对感染 SARS-CoV-2 的产妇所分娩的新生儿的特征进行了部分研究。目前尚无系统综述全面阐述新生儿的临床表现，包括可能的垂直传播。本研究通过PubMed、Google Scholar 和 Web of Science 进行了系统的文献检索，检索时间截至 2020 年 6 月 6 日。纳入了研究感染 SARS-CoV-2 的产妇所分娩的新生儿的研究。采用二项随机效应模型计算患病率及其 95%置信区间。荟萃分析纳入了 32 项研究共 261 例新生儿。大多数感染产妇所分娩的新生儿没有出现任何临床异常（80.4%）。临床特征为 11 例（42.3%）呼吸困难和 9 例（19.1%）发热。261 例新生儿中，有 120 例进行了感染检测，其中 12 例（10.0%）检测呈阳性。胎盘、脐血和阴道分泌物拭子检测均为阴性。新生儿大多未受母亲 SARS-CoV-2 感染的影响，垂直传播的风险较低。
