Ramot B, Ben-Bassat I
Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Princess Takamatsu Symp. 1987;18:87-94.
The possible effects of environmental factors on childhood lymphatic leukemia and intestinal lymphoma are reviewed. It is suggested that the subtype of childhood acute leukemia is determined by a spontaneous mutation in the proliferating lymphoid pool. The latter is affected by environmental factors such as the type of infections in the pediatric population. The changing leukemia subtype pattern in the Gaza Strip and the fact that intestinal lymphoma with malabsorption has practically disappeared from Israel strongly suggest that environmental factors do play a role in lymphatic malignancies.
本文综述了环境因素对儿童淋巴白血病和肠道淋巴瘤可能产生的影响。研究表明，儿童急性白血病的亚型由增殖性淋巴样细胞库中的自发突变决定。而后者会受到诸如儿童群体中感染类型等环境因素的影响。加沙地带白血病亚型模式的变化，以及以色列吸收不良型肠道淋巴瘤几乎消失这一事实，都有力地表明环境因素在淋巴系统恶性肿瘤中确实发挥着作用。
