CTLA-4 +49A/G 多态性增加中国汉族人群膀胱癌易感性：一项病例对照研究。
CTLA-4 +49A/G Polymorphism Increases the Susceptibility to Bladder Cancer in Chinese Han Participants: A Case-Control Study.
机构信息
Department of Urology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
出版信息
Dis Markers. 2020 Dec 1;2020:8143158. doi: 10.1155/2020/8143158. eCollection 2020.
Cytotoxic T cell antigen-4 (CTLA-4) is reportedly involved in the development of bladder cancer (BC). This research was designed to address the potential link between the +49A/G polymorphism in CTLA-4 gene and BC susceptibility. In total, 355 BC cases and 435 match controls from Chinese Han individuals were included eventually. The PCR-RFLR method was utilized to screen for this polymorphism. The +49A/G polymorphism was shown to increase the risk of BC. Subgroup analyses showed that this polymorphism was linked to an increased susceptibility to BC among individuals aged < 60 years, smokers and drinkers. Additionally, this polymorphism significantly correlated with tumor node metastasis and tumor size (≥3 cm). To sum up, this study reveals that the CTLA-4 +49A/G polymorphism could increase the risk of BC in Chinese Han people. Further large cohort studies with enough sample sizes are urgently warranted to verify the findings of this present study.
细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）据报道与膀胱癌（BC）的发生有关。本研究旨在探讨 CTLA-4 基因+49A/G 多态性与 BC 易感性之间的潜在联系。最终共纳入 355 例 BC 病例和 435 例匹配对照来自中国汉族个体。采用 PCR-RFLR 方法筛选该多态性。结果表明，+49A/G 多态性增加了 BC 的发病风险。亚组分析显示，该多态性与<60 岁、吸烟者和饮酒者的 BC 易感性增加相关。此外，该多态性与肿瘤淋巴结转移和肿瘤大小（≥3cm）显著相关。总之，本研究表明 CTLA-4+49A/G 多态性可能会增加中国汉族人群患 BC 的风险。进一步需要进行具有足够样本量的大型队列研究来验证本研究的结果。
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