Johansson Cecilia, Lind Marcus M, Eriksson Marie, Johansson Lars
Skellefteå Research Unit Department of Public Health and Clinical Medicine Umeå University Skellefteå Sweden.
Department of Statistics USBE Umeå University Umeå Sweden.
J Arrhythm. 2020 Jul 23;36(6):974-981. doi: 10.1002/joa3.12409. eCollection 2020 Dec.
Anthropometric factors are reported to be risk factors for atrial fibrillation (AF), but it is unclear whether weight change in mid-life is associated with AF. We aimed to study the possible associations of weight, height, and weight change with the risk of incident AF in men and women.
Our study cohort included 108 417 persons (51% women) who participated in a population-based health examination in northern Sweden at 30, 40, 50, or 60 years of age. The health examination included weight and height measurement and collection of data regarding cardiovascular risk factors. Within this cohort, 40 275 participants underwent two health examinations with a 10-year interval. We identified cases with a first-ever diagnosis of AF through the Swedish National Patient Registry.
During a total follow-up of 1 469 820 person-years, 5154 participants developed incident AF. The mean age at inclusion was 46.3 years, and mean age at AF diagnosis was 66.6 years. After adjustment for potential confounders, height, weight, body mass index (BMI), and body surface area (BSA) were positively associated with risk of incident AF in both men and women. Among participants who underwent two health examinations 10 years apart, 1142 persons developed AF. The mean weight change from baseline was a gain of 4.8%. Weight gain or weight loss was not significantly associated with risk of incident AF.
Height, weight, BMI, and BSA showed positive associations with risk of incident AF in both men and women. Midlife weight change was not significantly associated with AF risk.
据报道，人体测量因素是心房颤动（AF）的危险因素，但中年时期体重变化是否与AF相关尚不清楚。我们旨在研究体重、身高和体重变化与男性和女性发生AF风险之间的可能关联。
我们的研究队列包括108417人（51%为女性），他们在30、40、50或60岁时参加了瑞典北部基于人群的健康检查。健康检查包括体重和身高测量以及心血管危险因素数据的收集。在这个队列中，40275名参与者接受了间隔10年的两次健康检查。我们通过瑞典国家患者登记处确定了首次诊断为AF的病例。
在总共1469820人年的随访期间，5154名参与者发生了新发AF。纳入时的平均年龄为46.3岁，AF诊断时的平均年龄为66.6岁。在对潜在混杂因素进行调整后，身高、体重、体重指数（BMI）和体表面积（BSA）在男性和女性中均与新发AF风险呈正相关。在间隔10年接受两次健康检查的参与者中，1142人发生了AF。与基线相比，体重的平均变化为增加4.8%。体重增加或减少与新发AF风险无显著关联。
身高、体重、BMI和BSA在男性和女性中均与新发AF风险呈正相关。中年体重变化与AF风险无显著关联。
