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木犀草素改变幽门螺杆菌感染的胃癌CRL-1739细胞中MUC1细胞外结构域、sT抗原、ADAM-17、IL-8、IL-10和NF-κB的表达：一项初步研究。

Luteolin alters MUC1 extracellular domain, sT antigen, ADAM-17, IL-8, IL-10 and NF-κB expression in -infected gastric cancer CRL-1739 cells: A preliminary study.

作者信息

Radziejewska Iwona, Borzym-Kluczyk Małgorzata, Leszczyńska Katarzyna

机构信息

Department of Medical Chemistry, Medical University of Bialystok, Bialystok, 15-222 Podlaskie Voivodeship, Poland.

Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Bialystok, 15-222 Podlaskie Voivodeship, Poland.

出版信息

Biomed Rep. 2021 Feb;14(2):19. doi: 10.3892/br.2020.1395. Epub 2020 Nov 25.

DOI:10.3892/br.2020.1395
PMID:33335725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7739866/
Abstract

Luteolin is a natural flavonoid possessing certain beneficial pharmacological properties, including anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer properties. The majority of types of gastric cancer with chronic gastritis are caused by infection with (). The present study evaluated the effect of luteolin on a number of selected factors that are potentially involved in gastric cancer development. The study was performed using gastric cancer CRL-1739 cells treated with 30 µM luteolin and alone or combined. ELISA and reverse transcription PCR were used to assess the expression levels of MUC1, GalNAcα-R (Tn antigen) and NeuAcα2-3Galβ1-3GalNAc-R (sT antigen), ADAM-17, IL-8, IL-10 and NF-κB. and luteolin independently and in combination significantly reduced the expression levels of the extracellular domain of MUC1 in gastric cancer cells compared with the untreated control cells. ADAM-17 expression was reduced by treatment with the pathogen and luteolin. Additionally, both factors reduced sT antigen expression. Treatment with 30 ≤M luteolin significantly induced IL-8 expression at the mRNA and protein level, and the mRNA expression levels of IL-10 and NF-κB compared with the control. Both and luteolin induced IL-8 protein expression. The present preliminary results suggest that luteolin may be used to treat patients with gastric cancer.

摘要

木犀草素是一种具有某些有益药理特性的天然黄酮类化合物，包括抗氧化、抗炎、抗菌和抗癌特性。大多数伴有慢性胃炎的胃癌类型是由（）感染引起的。本研究评估了木犀草素对一些可能参与胃癌发展的特定因素的影响。该研究使用用30μM木犀草素处理的胃癌CRL - 1739细胞单独或联合处理。采用酶联免疫吸附测定（ELISA）和逆转录聚合酶链反应（RT - PCR）来评估黏蛋白1（MUC1）、N - 乙酰半乳糖胺α - 受体（Tn抗原）和唾液酸α2 - 3 - 半乳糖β1 - 3 - N - 乙酰半乳糖胺 - 受体（sT抗原）、解聚素和金属蛋白酶17（ADAM - 17）、白细胞介素 - 8（IL - 8）、白细胞介素 - 10（IL - 10）和核因子κB（NF - κB）的表达水平。与未处理的对照细胞相比，该病原体和木犀草素单独及联合处理均显著降低了胃癌细胞中MUC1细胞外结构域的表达水平。用该病原体和木犀草素处理可降低ADAM - 17的表达。此外，这两种因素均降低了sT抗原的表达。用30μM木犀草素处理与对照相比，在mRNA和蛋白质水平显著诱导了IL - 8的表达，以及IL - 10和NF - κB的mRNA表达水平。该病原体和木犀草素均诱导了IL - 8蛋白的表达。本初步结果表明木犀草素可用于治疗胃癌患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/077834cf31f0/br-14-02-01395-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/1112cbe7d828/br-14-02-01395-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/12912e699d71/br-14-02-01395-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/1eda96b27bf4/br-14-02-01395-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/2b94db969709/br-14-02-01395-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/1b23e2f64bef/br-14-02-01395-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/97fc7410429a/br-14-02-01395-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/406bd5c4284f/br-14-02-01395-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/077834cf31f0/br-14-02-01395-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/1112cbe7d828/br-14-02-01395-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/12912e699d71/br-14-02-01395-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/1eda96b27bf4/br-14-02-01395-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/2b94db969709/br-14-02-01395-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/1b23e2f64bef/br-14-02-01395-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/97fc7410429a/br-14-02-01395-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/406bd5c4284f/br-14-02-01395-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b74/7739866/077834cf31f0/br-14-02-01395-g07.jpg

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