El Haj Mohamad, Moustafa Ahmed A, Roche Jean, Pasquier Florence, Kapogiannis Dimitrios, Gallouj Karim, Antoine Pascal
Univ Nantes, Laboratoire de psychologie des Pays de la Loire, LPPL, EA 4638, F-44000 Nantes, France.
Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France.
Transl Neurosci. 2020 Jun 3;11(1):201-207. doi: 10.1515/tnsci-2020-0123. eCollection 2020.
Most research has mainly focused on the decline of the subjective experience in Alzheimer's disease (AD). However, few attempts have been made to evaluate whether subjective experience may be maintained in AD. In this narrative review, we attempt to provide a positive view, according to which patients with AD can enjoy, to some extent, subjective experience during memory retrieval. Memory and expression difficulties (e.g., aphasia) limit the ability of patients with AD to describe their memories, resulting in a little specificity of reported memories. However, according to the "authentic subjective experience" view, we propose in this study that the ability to mentally relive these memories could be preserved in the patients. By proposing the authentic subjective experience view, we attempt to provide an alternative view to the general consideration that the patients suffer a diminished subjective experience. This view can contribute to a larger clinical framework that gives a positive meaning to the subjective experience of patients with AD. Furthermore, several clinical and empirical implications can be drawn from the authentic subjective experience view, including the possibility to evaluate behavioral correlates of the subjective experience in AD.
大多数研究主要聚焦于阿尔茨海默病（AD）中主观体验的衰退。然而，很少有人尝试评估AD患者的主观体验是否能够得以维持。在这篇叙述性综述中，我们试图提供一种积极的观点，即AD患者在记忆提取过程中在一定程度上能够享有主观体验。记忆和表达困难（如失语）限制了AD患者描述其记忆的能力，导致所报告记忆的特异性较低。然而，根据“真实主观体验”观点，我们在本研究中提出，AD患者在脑海中重现这些记忆的能力可能得以保留。通过提出真实主观体验观点，我们试图为患者主观体验受损这一普遍观点提供另一种视角。该观点有助于构建一个更大的临床框架，赋予AD患者主观体验积极的意义。此外，从真实主观体验观点中可以得出一些临床和实证方面的启示，包括评估AD主观体验行为相关性的可能性。
